KEGG   NETWORK: N01314
Entry
N01314                      Network                                

Name
SARS-CoV-2 S to classical pathway of complement activation
Definition
S -> (IgG,IgM) -> ((C1QA,C1QB,C1QC)+C1R+C1S)) -> (C2+C4) -> C3 -> (C5+C6+C7+C8+C9)
  Expanded
K24152 -> 102723407 -> ((712,713,714)+715+716)) -> (717+(720,721)) -> 718 -> (727+729+730+(731,732,733)+735)
Class
nt06136 Complement activation (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
102723407  IGH; immunoglobulin heavy variable 4-38-2-like
712  C1QA; complement C1q A chain
713  C1QB; complement C1q B chain
714  C1QC; complement C1q C chain
715  C1R; complement C1r
716  C1S; complement C1s
717  C2; complement C2
720  C4A; complement C4A (Rodgers blood group)
721  C4B; complement C4B (Chido blood group)
718  C3; complement C3
727  C5; complement C5
729  C6; complement C6
730  C7; complement C7
731  C8A; complement C8 alpha chain
732  C8B; complement C8 beta chain
733  C8G; complement C8 gamma chain
735  C9; complement C9
Perturbant
K24152 (S)  S; SARS coronavirus spike glycoprotein
Reference
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol (2020)
DOI:10.1111/bph.15187
Reference
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost (2020)
DOI:10.1111/jth.14981
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