NETWORK: N01350 Help
Entry
Name
NNK/NNN to PI3K signaling pathway
Definition
(NNK,NNN) -> CHRNA9 -> PI3K -> PIP3 -> AKT -> (ESR1/2,AP1) => (CHRNA9,CCND3)
Expanded
(C16453,C16452) -> 55584 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (2099,2100,(2353,3725)) => (55584,896)
Class
Type
Env factor
Pathway
hsa05207 Chemical carcinogenesis - receptor activation
Disease
Gene
55584 CHRNA9; cholinergic receptor nicotinic alpha 9 subunit
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
2099 ESR1; estrogen receptor 1
2100 ESR2; estrogen receptor 2
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Perturbant
C16453 (NNK) 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN) N'-Nitrosonornicotine
Metabolite
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
Title
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
Journal
Reference
Authors
Gankhuyag N, Lee KH, Cho JY
Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
Journal
Reference
Authors
Wu CH, Lee CH, Ho YS
Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
Journal
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