KEGG   NETWORK: N01350
Entry
N01350                      Network                                

Name
NNK/NNN to PI3K signaling pathway
Definition
(NNK,NNN) -> CHRNA9 -> PI3K -> PIP3 -> AKT -> (ESR1/2,AP1) => (CHRNA9,CCND3)
  Expanded
(C16453,C16452) -> 55584 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (2099,2100,(2353,3725)) => (55584,896)
Class
nt06214 PI3K signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
55584  CHRNA9; cholinergic receptor nicotinic alpha 9 subunit
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2099  ESR1; estrogen receptor 1
2100  ESR2; estrogen receptor 2
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
896  CCND3; cyclin D3
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN)  N'-Nitrosonornicotine
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
  Title
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
  Journal
Breast Cancer Res Treat 129:331-45 (2011)
DOI:10.1007/s10549-010-1209-0
Reference
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
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