| Entry |
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| Name |
BPA to RAS-ERK signaling pathway
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| Definition |
BPA -> ESR1/2 -> SRC -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
C13624 -> (2099,2100) -> 6714 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
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| Gene |
| 2099 | ESR1; estrogen receptor 1 |
| 2100 | ESR2; estrogen receptor 2 |
| 6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Perturbant |
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| Reference |
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| Authors |
Murata M, Kang JH |
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| Title |
Bisphenol A (BPA) and cell signaling pathways. |
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| Journal |
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| Reference |
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| Authors |
Buteau-Lozano H, Velasco G, Cristofari M, Balaguer P, Perrot-Applanat M |
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| Title |
Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism. |
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| Journal |
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| LinkDB |
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