| Entry |
|
|---|
| Name |
Arsenic to electron transfer in complex II
|
|---|
| Definition |
As -- AS3MT >> GSTO1 -> MMA -| CxII |
|---|
| Expanded |
C20296 -- 57412 >> 9446 -> C07295 -| (6389+6390+6391+6392) |
|---|
| Class |
nt06252 Mitochondrial ROS formation (cancer)
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 57412 | AS3MT; arsenite methyltransferase |
| 9446 | GSTO1; glutathione S-transferase omega 1 |
| 6389 | SDHA; succinate dehydrogenase complex flavoprotein subunit A |
| 6390 | SDHB; succinate dehydrogenase complex iron sulfur subunit B |
| 6391 | SDHC; succinate dehydrogenase complex subunit C |
| 6392 | SDHD; succinate dehydrogenase complex subunit D |
|
|---|
| Perturbant |
|
|---|
| Metabolite |
|
|---|
| Reference |
|
|---|
| Authors |
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD |
|---|
| Title |
Molecular features in arsenic-induced lung tumors. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Henkler F, Brinkmann J, Luch A |
|---|
| Title |
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y |
|---|
| Title |
The Role of Reactive Oxygen Species in Arsenic Toxicity. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Faita F, Cori L, Bianchi F, Andreassi MG |
|---|
| Title |
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
