| Entry |
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|---|
| Name |
Arsenic to electron transfer in complex II
|
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| Definition |
As -- AS3MT >> GSTO1 >> AS3MT -> DMA -| CxII |
|---|
| Expanded |
C20296 -- 57412 >> 9446 >> 57412 -> C20300 -| (6389+6390+6391+6392) |
|---|
| Class |
nt06252 Mitochondrial ROS formation (cancer)
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 57412 | AS3MT; arsenite methyltransferase |
| 9446 | GSTO1; glutathione S-transferase omega 1 |
| 6389 | SDHA; succinate dehydrogenase complex flavoprotein subunit A |
| 6390 | SDHB; succinate dehydrogenase complex iron sulfur subunit B |
| 6391 | SDHC; succinate dehydrogenase complex subunit C |
| 6392 | SDHD; succinate dehydrogenase complex subunit D |
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|---|
| Perturbant |
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| Metabolite |
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| Reference |
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| Authors |
Naranmandura H, Xu S, Sawata T, Hao WH, Liu H, Bu N, Ogra Y, Lou YJ, Suzuki N |
|---|
| Title |
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity. |
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| Journal |
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| LinkDB |
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