KEGG   NETWORK: N01395
Entry
N01395                      Network                                

Name
Cadmium to electron transfer in complex III
Definition
Cd -| CxIII
  Expanded
C01413 -| (7386+4519+1537+7384+7385+(440567,7388)+7381+27089+29796+10975)
Class
nt06252 Mitochondrial ROS formation
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00021  Renal cell carcinoma
H00024  Prostate cancer
Gene
7386  UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
4519  CYTB; cytochrome b
1537  CYC1; cytochrome c1
7384  UQCRC1; ubiquinol-cytochrome c reductase core protein 1
7385  UQCRC2; ubiquinol-cytochrome c reductase core protein 2
440567  UQCRHL; ubiquinol-cytochrome c reductase hinge protein like
7388  UQCRH; ubiquinol-cytochrome c reductase hinge protein
7381  UQCRB; ubiquinol-cytochrome c reductase binding protein
27089  UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII
29796  UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X
10975  UQCR11; ubiquinol-cytochrome c reductase, complex III subunit XI
Perturbant
C01413 (Cd)  Cadmium
Reference
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
  Authors
Wang Y, Fang J, Leonard SS, Rao KM
  Title
Cadmium inhibits the electron transfer chain and induces reactive oxygen species.
  Journal
Free Radic Biol Med 36:1434-43 (2004)
DOI:10.1016/j.freeradbiomed.2004.03.010
Reference
  Authors
Waalkes MP
  Title
Cadmium carcinogenesis.
  Journal
Mutat Res 533:107-20 (2003)
DOI:10.1016/j.mrfmmm.2003.07.011
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