KEGG   Homo sapiens (human): 5423
Entry
5423              CDS       T01001                                 
Symbol
POLB
Name
(RefSeq) DNA polymerase beta
  KO
K02330  DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03410  Base excision repair
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
Network
nt06140  Transcription (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
  Element
N00511  HTLV-1 Tax to E47-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    5423 (POLB)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    5423 (POLB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5423 (POLB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5423 (POLB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5423 (POLB)
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.99  Other carbon-oxygen lyases
    4.2.99.-
     5423 (POLB)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Short Patch-BER factors
     5423 (POLB)
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    X-family DNA polymerases
     5423 (POLB)
SSDB
Motif
Pfam: DNA_pol_B_palm DNA_pol_lambd_f HHH_8 DNA_pol_B_thumb HHH_5 HHH Cdd1 HHH_2 NTP_transf_2
Other DBs
NCBI-GeneID: 5423
NCBI-ProteinID: NP_002681
OMIM: 174760
HGNC: 9174
Ensembl: ENSG00000070501
Pharos: P06746(Tchem)
UniProt: P06746
Structure
LinkDB
Position
8:42338494..42371808
AA seq 335 aa
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
NT seq 1008 nt   +upstreamnt  +downstreamnt
atgagcaaacggaaggcgccgcaggagactctcaacgggggaatcaccgacatgctcaca
gaactcgcaaactttgagaagaacgtgagccaagctatccacaagtacaatgcttacaga
aaagcagcatctgttatagcaaaatacccacacaaaataaagagtggagctgaagctaag
aaattgcctggagtaggaacaaaaattgctgaaaagattgatgagtttttagcaactgga
aaattacgtaaactggaaaagattcggcaggatgatacgagttcatccatcaatttcctg
actcgagttagtggcattggtccatctgctgcaaggaagtttgtagatgaaggaattaaa
acactagaagatctcagaaaaaatgaagataaattgaaccatcatcagcgaattgggctg
aaatattttggggactttgaaaaaagaattcctcgtgaagagatgttacaaatgcaagat
attgtactaaatgaagttaaaaaagtggattctgaatacattgctacagtctgtggcagt
ttcagaagaggtgcagagtccagtggtgacatggatgttctcctgacccatcccagcttc
acttcagaatcaaccaaacagccaaaactgttacatcaggttgtggagcagttacaaaag
gttcattttatcacagataccctgtcaaagggtgagacaaagttcatgggtgtttgccag
cttcccagtaaaaatgatgaaaaagaatatccacacagaagaattgatatcaggttgata
cccaaagatcagtattactgtggtgttctctatttcactgggagtgatattttcaataag
aatatgagggctcatgccctagaaaagggtttcacaatcaatgagtacaccatccgtccc
ttgggagtcactggagttgcaggagaacccctgccagtggatagtgaaaaagacatcttt
gattacatccagtggaaataccgggaacccaaggaccggagcgaatga

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