KEGG   NETWORK: N01515
Entry
N01515                      Network                                
Name
Regulation of coagulation cascade, protein C system
Definition
PROC -- (F2a+THBD+PROCR) -> APC -> (APC+PROS1) -| (F5a,F8a)
  Expanded
5624 -- (C00752+7056+10544) -> C22547 -> (C22547+5627) -| (C03780,C04001)
Class
nt06514 Coagulation cascade
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
5624  PROC; protein C, inactivator of coagulation factors Va and VIIIa
7056  THBD; thrombomodulin
10544  PROCR; protein C receptor
5627  PROS1; protein S
Metabolite
C00752  Thrombin
C22547  APC
C03780  Coagulation factor Va
C04001  Coagulation factor VIIIa
Reference
PMID:19466992
  Authors
Neyrinck AP, Liu KD, Howard JP, Matthay MA
  Title
Protective mechanisms of activated protein C in severe inflammatory disorders.
  Journal
Br J Pharmacol 158:1034-47 (2009)
DOI:10.1111/j.1476-5381.2009.00251.x
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