KEGG   NETWORK: N01539
Entry
N01539                      Network                                
Name
RAD51 -dsDNA destabilization
Definition
RFWD3 -| RPA,RAD51 == BCDX2+HELQ
  Expanded
55159 -| (6117+6118+6119+29935),5888 == (5890+5889+5892+7516)+113510
Class
nt06508 Interstrand crosslink repair
Type
Reference
Pathway
hsa03460  Fanconi anemia pathway
hsa03440  Homologous recombination
Gene
55159  RFWD3; ring finger and WD repeat domain 3
6117  RPA1; replication protein A1
6118  RPA2; replication protein A2
6119  RPA3; replication protein A3
29935  RPA4; replication protein A4
5888  RAD51; RAD51 recombinase
5890  RAD51B; RAD51 paralog B
5889  RAD51C; RAD51 paralog C
5892  RAD51D; RAD51 paralog D
7516  XRCC2; X-ray repair cross complementing 2
113510  HELQ; helicase, POLQ like
Reference
PMID:28575658
  Authors
Inano S, Sato K, Katsuki Y, Kobayashi W, Tanaka H, Nakajima K, Nakada S, Miyoshi H, Knies K, Takaori-Kondo A, Schindler D, Ishiai M, Kurumizaka H, Takata M
  Title
RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.
  Journal
Mol Cell 66:622-634.e8 (2017)
DOI:10.1016/j.molcel.2017.04.022
Reference
PMID:31575675
  Authors
Saredi G, Rouse J
  Title
Ways to unwind with HROB, a new player in homologous recombination.
  Journal
Genes Dev 33:1293-1294 (2019)
DOI:10.1101/gad.331850.119
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