KEGG   NETWORK: N01556
Entry
N01556                      Network                                
Name
IL6 family to Jak-STAT signaling pathway
Definition
(IL6,IL11,IL13,IL27,IL31,OSM,LIF,CNTF,CTF1,CLCF1) -> ((IL6ST+(IL6R,IL11RA,IL27RA,OSMR,LIFR,CNTFR)),(IL4R+IL13RA),(IL31RA+OSMR)) -> (JAK1+JAK2+TYK2) -> (STAT1,STAT3,STAT6)
  Expanded
(3569,3589,3596,246778,386653,5008,3976,1270,1489,23529) -> ((3572+(3570,3590,9466,9180,3977,1271)),(3566+3597+3598),(133396+9180)) -> (3716+3717+7297) -> (6772,6774,6778)
Class
nt06518 JAK-STAT signaling
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3569  IL6; interleukin 6
3589  IL11; interleukin 11
3596  IL13; interleukin 13
246778  IL27; interleukin 27
386653  IL31; interleukin 31
5008  OSM; oncostatin M
3976  LIF; LIF interleukin 6 family cytokine
1270  CNTF; ciliary neurotrophic factor
1489  CTF1; cardiotrophin 1
23529  CLCF1; cardiotrophin like cytokine factor 1
3572  IL6ST; interleukin 6 cytokine family signal transducer
3570  IL6R; interleukin 6 receptor
3590  IL11RA; interleukin 11 receptor subunit alpha
9466  IL27RA; interleukin 27 receptor subunit alpha
9180  OSMR; oncostatin M receptor
3977  LIFR; LIF receptor subunit alpha
1271  CNTFR; ciliary neurotrophic factor receptor
3566  IL4R; interleukin 4 receptor
3597  IL13RA1; interleukin 13 receptor subunit alpha 1
3598  IL13RA2; interleukin 13 receptor subunit alpha 2
133396  IL31RA; interleukin 31 receptor A
3716  JAK1; Janus kinase 1
3717  JAK2; Janus kinase 2
7297  TYK2; tyrosine kinase 2
6772  STAT1; signal transducer and activator of transcription 1
6774  STAT3; signal transducer and activator of transcription 3
6778  STAT6; signal transducer and activator of transcription 6
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
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