KEGG   NETWORK: N01716
Entry
N01716                      Network                                
Name
Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
Definition
Ubiquitinated_protein == (SQSTM1,NBR1,OPTN,CALCOCO2,TAX1BP1,WDFY3) == LC3-II
  Expanded
(7311,6233,7314,7316) == (8878,4077,10133,10241,8887,23001) == ((84557,81631,643246,440738)+C00350)
Class
nt06532 Autophagy
Type
Reference
Pathway
hsa04140  Autophagy - animal
Gene
7311  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1
6233  RPS27A; ribosomal protein S27a
7314  UBB; ubiquitin B
7316  UBC; ubiquitin C
8878  SQSTM1; sequestosome 1
4077  NBR1; NBR1 autophagy cargo receptor
10133  OPTN; optineurin
10241  CALCOCO2; calcium binding and coiled-coil domain 2
8887  TAX1BP1; Tax1 binding protein 1
23001  WDFY3; WD repeat and FYVE domain containing 3
84557  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha
81631  MAP1LC3B; microtubule associated protein 1 light chain 3 beta
643246  MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2
440738  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma
Metabolite
C00350  Phosphatidylethanolamine
Reference
  Authors
Ma S, Attarwala IY, Xie XQ
  Title
SQSTM1/p62: A Potential Target for Neurodegenerative Disease.
  Journal
ACS Chem Neurosci 10:2094-2114 (2019)
DOI:10.1021/acschemneuro.8b00516
Reference
  Authors
Jeong SJ, Zhang X, Rodriguez-Velez A, Evans TD, Razani B
  Title
p62/SQSTM1 and Selective Autophagy in Cardiometabolic Diseases.
  Journal
Antioxid Redox Signal 31:458-471 (2019)
DOI:10.1089/ars.2018.7649
Reference
  Authors
Farre JC, Subramani S
  Title
Mechanistic insights into selective autophagy pathways: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 17:537-52 (2016)
DOI:10.1038/nrm.2016.74
Reference
  Authors
Kirkin V, Rogov VV
  Title
A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway.
  Journal
Mol Cell 76:268-285 (2019)
DOI:10.1016/j.molcel.2019.09.005
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