Homo sapiens (human): 1109
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Entry
1109 CDS
T01001
Symbol
AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Name
(RefSeq) aldo-keto reductase family 1 member C4
KO
K00037
3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:
1.1.1.50
1.1.1.357
1.1.1.225
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00120
Primary bile acid biosynthesis
hsa00140
Steroid hormone biosynthesis
hsa01100
Metabolic pathways
hsa05208
Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00104
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Network
nt06022
Bile acid biosynthesis
nt06226
KEAP1-NRF2 signaling
nt06251
CYP-mediated ROS formation
Element
N00805
Bile acid biosynthesis
N01401
Benzo[a]pyrenre to CYP-mediated metabolism
N01413
Metals to KEAP1-NRF2 signalig pathway
Disease
H00607
46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00120 Primary bile acid biosynthesis
1109 (AKR1C4)
00140 Steroid hormone biosynthesis
1109 (AKR1C4)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
1109 (AKR1C4)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1109 (AKR1C4)
1.1.1.225 chlordecone reductase
1109 (AKR1C4)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
1109 (AKR1C4)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Aldo_ket_red
Motif
Other DBs
NCBI-GeneID:
1109
NCBI-ProteinID:
NP_001809
OMIM:
600451
HGNC:
387
Ensembl:
ENSG00000198610
Pharos:
P17516
(Tbio)
UniProt:
P17516
Structure
PDB
LinkDB
All DBs
Position
10:5196837..5218949
Genome browser
AA seq
323 aa
AA seq
DB search
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
NT seq
972 nt
NT seq
+upstream
nt +downstream
nt
atggatcccaaatatcagcgtgtagagctaaatgatggtcacttcatgcccgtattggga
tttggcacctatgcacctccagaggttccgaggaacagagctgtagaggtcaccaaatta
gcaatagaagctggcttccgccatattgattctgcttatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtgcactttctttcaaccacagatggtccaaccagccttggaa
agctcactgaaaaaacttcaactggactatgttgacctctatcttcttcatttcccaatg
gctctcaagccaggtgagacgccactaccaaaagatgaaaatggaaaagtaatattcgac
acagtggatctctctgccacatgggaggtcatggagaagtgtaaggatgcaggattggcc
aagtccatcggggtgtcaaacttcaactgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccttacctcaaccagagc
aaactgctggatttctgcaagtcaaaagacattgttctggttgcccacagtgctctggga
acccaacgacataaactatgggtggacccaaactccccagttcttttggaggacccagtt
ctttgtgccttagcaaagaaacacaaacaaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcggatcagagagaac
atccaggtttttgaattccagttgacatcagaggatatgaaagttctagatggtctaaac
agaaattatcgatatgttgtcatggattttcttatggaccatcctgattatccattttca
gatgaatattag
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