KEGG   NETWORK: N01815
Entry
N01815                      Network                                
Name
Vinculin-talin-integrin macromolecular complex
Definition
ECM == LAMA == (ITGA+ITGB) == TLN == VCL == ACTN == ACTB/G == Z-disc
  Expanded
ECM == (284217,3908) == ((3672+3688),(3673+3688),(3675+3688),(3655+3688),(3679+3688),(3655+3691)) == (7094,83660) == 7414 == (88,89) == (60,71,72) == Z-disc
Class
nt06539 Cytoskeleton in muscle cells
Type
Reference
Pathway
hsa04820  Cytoskeleton in muscle cells
Gene
284217  LAMA1; laminin subunit alpha 1
3908  LAMA2; laminin subunit alpha 2
3672  ITGA1; integrin subunit alpha 1
3688  ITGB1; integrin subunit beta 1
3673  ITGA2; integrin subunit alpha 2
3675  ITGA3; integrin subunit alpha 3
3655  ITGA6; integrin subunit alpha 6
3679  ITGA7; integrin subunit alpha 7
3691  ITGB4; integrin subunit beta 4
7094  TLN1; talin 1
83660  TLN2; talin 2
7414  VCL; vinculin
88  ACTN2; actinin alpha 2
89  ACTN3; actinin alpha 3
60  ACTB; actin beta
71  ACTG1; actin gamma 1
72  ACTG2; actin gamma 2, smooth muscle
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Dwyer J, Iskratsch T, Ehler E
  Title
Actin in striated muscle: recent insights into assembly and maintenance.
  Journal
Biophys Rev 4:17-25 (2012)
DOI:10.1007/s12551-011-0062-7
LinkDB

DBGET integrated database retrieval system