Homo sapiens (human): 3691
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Entry
3691 CDS
T01001
Symbol
ITGB4, CD104, GP150, JEB5A, JEB5B
Name
(RefSeq) integrin subunit beta 4
KO
K06525
integrin beta 4
Organism
hsa
Homo sapiens (human)
Pathway
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa04512
ECM-receptor interaction
hsa04810
Regulation of actin cytoskeleton
hsa04820
Cytoskeleton in muscle cells
hsa05165
Human papillomavirus infection
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06539
Cytoskeleton in muscle cells
Element
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00951
ITGA/B-RHOG-RAC signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01072
ITGA/B-RhoGEF-RhoA signaling pathway
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01815
Vinculin-talin-integrin macromolecular complex
Disease
H00586
Epidermolysis bullosa, junctional
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
3691 (ITGB4)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
3691 (ITGB4)
09140 Cellular Processes
09142 Cell motility
04820 Cytoskeleton in muscle cells
3691 (ITGB4)
09160 Human Diseases
09172 Infectious disease: viral
05165 Human papillomavirus infection
3691 (ITGB4)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3691 (ITGB4)
05412 Arrhythmogenic right ventricular cardiomyopathy
3691 (ITGB4)
05414 Dilated cardiomyopathy
3691 (ITGB4)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3691 (ITGB4)
04515 Cell adhesion molecules [BR:
hsa04515
]
3691 (ITGB4)
04090 CD molecules [BR:
hsa04090
]
3691 (ITGB4)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
3691 (ITGB4)
Exosomal proteins of bladder cancer cells
3691 (ITGB4)
Cell adhesion molecules [BR:
hsa04515
]
Integrins
Integrin beta subunits
3691 (ITGB4)
CD molecules [BR:
hsa04090
]
Proteins
3691 (ITGB4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Integrin_beta
fn3
Calx-beta
Integrin_B_tail
Pur_ac_phosph_N
I-EGF_1
Ig_DSCAM-DSCAML_C
EGF_Teneurin
PSI_integrin
EGF_integrin
EGF_TEN
EGF_2
vWA_SIBA-E
SEA
Motif
Other DBs
NCBI-GeneID:
3691
NCBI-ProteinID:
NP_000204
OMIM:
147557
HGNC:
6158
Ensembl:
ENSG00000132470
UniProt:
P16144
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:75721459..75757818
Genome browser
AA seq
1822 aa
AA seq
DB search
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRR
CNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFEL
EVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAIL
QTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYR
TQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDG
THVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCV
CSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGR
CHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDE
LKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLL
LLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLR
SGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTREC
AQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLK
LTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQL
LVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGG
KSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFH
VQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGS
RKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYG
AQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLV
NDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQP
KRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLG
EELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGE
HLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEH
SHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGY
SVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIES
QVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEM
AQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGG
PFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEF
VSRTLTTSGTLSTHMDQQFFQT
NT seq
5469 nt
NT seq
+upstream
nt +downstream
nt
atggcagggccacgccccagcccatgggccaggctgctcctggcagccttgatcagcgtc
agcctctctgggaccttggcaaaccgctgcaagaaggccccagtgaagagctgcacggag
tgtgtccgtgtggataaggactgcgcctactgcacagacgagatgttcagggaccggcgc
tgcaacacccaggcggagctgctggccgcgggctgccagcgggagagcatcgtggtcatg
gagagcagcttccaaatcacagaggagacccagattgacaccaccctgcggcgcagccag
atgtccccccaaggcctgcgggtccgtctgcggcccggtgaggagcggcattttgagctg
gaggtgtttgagccactggagagccccgtggacctgtacatcctcatggacttctccaac
tccatgtccgatgatctggacaacctcaagaagatggggcagaacctggctcgggtcctg
agccagctcaccagcgactacactattggatttggcaagtttgtggacaaagtcagcgtc
ccgcagacggacatgaggcctgagaagctgaaggagccctggcccaacagtgaccccccc
ttctccttcaagaacgtcatcagcctgacagaagatgtggatgagttccggaataaactg
cagggagagcggatctcaggcaacctggatgctcctgagggcggcttcgatgccatcctg
cagacagctgtgtgcacgagggacattggctggcgcccggacagcacccacctgctggtc
ttctccaccgagtcagccttccactatgaggctgatggcgccaacgtgctggctggcatc
atgagccgcaacgatgaacggtgccacctggacaccacgggcacctacacccagtacagg
acacaggactacccgtcggtgcccaccctggtgcgcctgctcgccaagcacaacatcatc
cccatctttgctgtcaccaactactcctatagctactacgagaagcttcacacctatttc
cctgtctcctcactgggggtgctgcaggaggactcgtccaacatcgtggagctgctggag
gaggccttcaatcggatccgctccaacctggacatccgggccctagacagcccccgaggc
cttcggacagaggtcacctccaagatgttccagaagacgaggactgggtcctttcacatc
cggcggggggaagtgggtatataccaggtgcagctgcgggcccttgagcacgtggatggg
acgcacgtgtgccagctgccggaggaccagaagggcaacatccatctgaaaccttccttc
tccgacggcctcaagatggacgcgggcatcatctgtgatgtgtgcacctgcgagctgcaa
aaagaggtgcggtcagctcgctgcagcttcaacggagacttcgtgtgcggacagtgtgtg
tgcagcgagggctggagtggccagacctgcaactgctccaccggctctctgagtgacatt
cagccctgcctgcgggagggcgaggacaagccgtgctccggccgtggggagtgccagtgc
gggcactgtgtgtgctacggcgaaggccgctacgagggtcagttctgcgagtatgacaac
ttccagtgtccccgcacttccgggttcctctgcaatgaccgaggacgctgctccatgggc
cagtgtgtgtgtgagcctggttggacaggcccaagctgtgactgtcccctcagcaatgcc
acctgcatcgacagcaatgggggcatctgtaatggacgtggccactgtgagtgtggccgc
tgccactgccaccagcagtcgctctacacggacaccatctgcgagatcaactactcggcg
atccacccgggcctctgcgaggacctacgctcctgcgtgcagtgccaggcgtggggcacc
ggcgagaagaaggggcgcacgtgtgaggaatgcaacttcaaggtcaagatggtggacgag
cttaagagagccgaggaggtggtggtgcgctgctccttccgggacgaggatgacgactgc
acctacagctacaccatggaaggtgacggcgcccctgggcccaacagcactgtcctggtg
cacaagaagaaggactgccctccgggctccttctggtggctcatccccctgctcctcctc
ctcctgccgctcctggccctgctactgctgctatgctggaagtactgtgcctgctgcaag
gcctgcctggcacttctcccgtgctgcaaccgaggtcacatggtgggctttaaggaagac
cactacatgctgcgggagaacctgatggcctctgaccacttggacacgcccatgctgcgc
agcgggaacctcaagggccgtgacgtggtccgctggaaggtcaccaacaacatgcagcgg
cctggctttgccactcatgccgccagcatcaaccccacagagctggtgccctacgggctg
tccttgcgcctggcccgcctttgcaccgagaacctgctgaagcctgacactcgggagtgc
gcccagctgcgccaggaggtggaggagaacctgaacgaggtctacaggcagatctccggt
gtacacaagctccagcagaccaagttccggcagcagcccaatgccgggaaaaagcaagac
cacaccattgtggacacagtgctgatggcgccccgctcggccaagccggccctgctgaag
cttacagagaagcaggtggaacagagggccttccacgacctcaaggtggcccccggctac
tacaccctcactgcagaccaggacgcccggggcatggtggagttccaggagggcgtggag
ctggtggacgtacgggtgcccctctttatccggcctgaggatgacgacgagaagcagctg
ctggtggaggccatcgacgtgcccgcaggcactgccaccctcggccgccgcctggtaaac
atcaccatcatcaaggagcaagccagagacgtggtgtcctttgagcagcctgagttctcg
gtcagccgcggggaccaggtggcccgcatccctgtcatccggcgtgtcctggacggcggg
aagtcccaggtctcctaccgcacacaggatggcaccgcgcagggcaaccgggactacatc
cccgtggagggtgagctgctgttccagcctggggaggcctggaaagagctgcaggtgaag
ctcctggagctgcaagaagttgactccctcctgcggggccgccaggtccgccgtttccac
gtccagctcagcaaccctaagtttggggcccacctgggccagccccactccaccaccatc
atcatcagggacccagatgaactggaccggagcttcacgagtcagatgttgtcatcacag
ccaccccctcacggcgacctgggcgccccgcagaaccccaatgctaaggccgctgggtcc
aggaagatccatttcaactggctgcccccttctggcaagccaatggggtacagggtaaag
tactggattcagggtgactccgaatccgaagcccacctgctcgacagcaaggtgccctca
gtggagctcaccaacctgtacccgtattgcgactatgagatgaaggtgtgcgcctacggg
gctcagggcgagggaccctacagctccctggtgtcctgccgcacccaccaggaagtgccc
agcgagccagggcgtctggccttcaatgtcgtctcctccacggtgacccagctgagctgg
gctgagccggctgagaccaacggtgagatcacagcctacgaggtctgctatggcctggtc
aacgatgacaaccgacctattgggcccatgaagaaagtgctggttgacaaccctaagaac
cggatgctgcttattgagaaccttcgggagtcccagccctaccgctacacggtgaaggcg
cgcaacggggccggctgggggcctgagcgggaggccatcatcaacctggccacccagccc
aagaggcccatgtccatccccatcatccctgacatccctatcgtggacgcccagagcggg
gaggactacgacagcttccttatgtacagcgatgacgttctacgctctccatcgggcagc
cagaggcccagcgtctccgatgacactggctgcggctggaagttcgagcccctgctgggg
gaggagctggacctgcggcgcgtcacgtggcggctgcccccggagctcatcccgcgcctg
tcggccagcagcgggcgctcctccgacgccgaggcgccccacgggcccccggacgacggc
ggcgcgggcgggaagggcggcagcctgccccgcagtgcgacacccgggccccccggagag
cacctggtgaatggccggatggactttgccttcccgggcagcaccaactccctgcacagg
atgaccacgaccagtgctgctgcctatggcacccacctgagcccacacgtgccccaccgc
gtgctaagcacatcctccaccctcacacgggactacaactcactgacccgctcagaacac
tcacactcgaccacactgcccagggactactccaccctcacctccgtctcctcccacgac
tctcgcctgactgctggtgtgcccgacacgcccacccgcctggtgttctctgccctgggg
cccacatctctcagagtgagctggcaggagccgcggtgcgagcggccgctgcagggctac
agtgtggagtaccagctgctgaacggcggtgagctgcatcggctcaacatccccaaccct
gcccagacctcggtggtggtggaagacctcctgcccaaccactcctacgtgttccgcgtg
cgggcccagagccaggaaggctggggccgagagcgtgagggtgtcatcaccattgaatcc
caggtgcacccgcagagcccactgtgtcccctgccaggctccgccttcactttgagcact
cccagtgccccaggcccgctggtgttcactgccctgagcccagactcgctgcagctgagc
tgggagcggccacggaggcccaatggggatatcgtcggctacctggtgacctgtgagatg
gcccaaggaggagggccagccaccgcattccgggtggatggagacagccccgagagccgg
ctgaccgtgccgggcctcagcgagaacgtgccctacaagttcaaggtgcaggccaggacc
actgagggcttcgggccagagcgcgagggcatcatcaccatagagtcccaggatggagga
cccttcccgcagctgggcagccgtgccgggctcttccagcacccgctgcaaagcgagtac
agcagcatcaccaccacccacaccagcgccaccgagcccttcctagtggatgggctgacc
ctgggggcccagcacctggaggcaggcggctccctcacccggcatgtgacccaggagttt
gtgagccggacactgaccaccagcggaacccttagcacccacatggaccaacagttcttc
caaacttga
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