KEGG   NETWORK: N01879
Entry
N01879                      Network                                
Name
Glutamate-GRM-GNAI/O signaling pathway
Definition
Glutamate -> GRM -> (GNAI,GNAO) -| ADCY
  Expanded
C00025 -> (2912,2913,2914,2916,2917,2918) -> ((2770,2771,2773),2775) -| (107,108,109,196883,111,112,113,114,115)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
hsa04082  Neuroactive ligand signaling
Gene
2912  GRM2; glutamate metabotropic receptor 2
2913  GRM3; glutamate metabotropic receptor 3
2914  GRM4; glutamate metabotropic receptor 4
2916  GRM6; glutamate metabotropic receptor 6
2917  GRM7; glutamate metabotropic receptor 7
2918  GRM8; glutamate metabotropic receptor 8
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
2775  GNAO1; G protein subunit alpha o1
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
Metabolite
C00025  L-Glutamate
Reference
PMID:17706608
  Authors
Gass JT, Olive MF
  Title
Glutamatergic substrates of drug addiction and alcoholism.
  Journal
Biochem Pharmacol 75:218-65 (2008)
DOI:10.1016/j.bcp.2007.06.039
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