KEGG   NETWORK: N02046
Entry
N02046                      Network                                
Name
Formation of the ternary complex (TC) for ribosomal translation initiation
Definition
eIF2+GDP -- EIF2B -> eIF2+GTP == Met-tRNAi
  Expanded
(1965+8894+1968)+C00035 -- (1967+8892+8891+8890+8893) -> (1965+8894+1968)+C00044 == 7210,100189015,100189094,100189040,100189315,100189255
Class
nt06552 Integrated stress response (ISR) signaling pathway
Type
Reference
Pathway
hsa04156 Integrated stress response (ISR) signaling pathway   
Gene
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit 1
8894  EIF2S2; eukaryotic translation initiation factor 2 subunit 2 isoform 1
1968  EIF2S3; eukaryotic translation initiation factor 2 subunit 3
1967  EIF2B1; translation initiation factor eIF2B subunit alpha
8892  EIF2B2; translation initiation factor eIF2B subunit beta
8891  EIF2B3; translation initiation factor eIF2B subunit gamma isoform 1
8890  EIF2B4; translation initiation factor eIF2B subunit delta isoform 2
8893  EIF2B5; translation initiation factor eIF2B subunit epsilon
7210  TRX-CAT1-2; tRNA-Met
100189015  TRX-CAT1-1; tRNA-Met
100189094  TRX-CAT1-3; tRNA-Met
100189040  TRX-CAT1-4; tRNA-Met
100189315  TRX-CAT1-7; tRNA-Met
100189255  TRX-CAT1-8; tRNA-Met
Metabolite
C00035  GDP
C00044  GTP
Reference
PMID:32200625
  Authors
Marintchev A, Ito T
  Title
eIF2B and the Integrated Stress Response: A Structural and Mechanistic View.
  Journal
Biochemistry 59:1299-1308 (2020)
DOI:10.1021/acs.biochem.0c00132
Reference
PMID:26636041
  Authors
Holcik M
  Title
Could the eIF2alpha-Independent Translation Be the Achilles Heel of Cancer?
  Journal
Front Oncol 5:264 (2015)
DOI:10.3389/fonc.2015.00264
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