KEGG   NETWORK: N02048
Entry
N02048                      Network                                
Name
Inactive complex formation by phosphorylation of eIF2alpha
Definition
(EIF2AK1,EIF2AK2,EIF2AK3,EIF2AK4) -- (EIF2S1+Pi)+(EIF2S2+EIF2S3)+GDP -> (EIF2S1+Pi+EIF2S2+EIF2S3+GDP+EIF2B)
  Expanded
(27102,5610,9451,440275) -- (1965+C00009)+(8894+1968)+C00035 -> (1965+C00009+8894+1968+C00035+1967+8892+8891+8890+8893)
Class
nt06552 Integrated stress response (ISR) signaling pathway
Type
Reference
Pathway
hsa04156 Integrated stress response (ISR) signaling pathway   
Gene
27102  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform a
5610  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform a
9451  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor
440275  EIF2AK4; eIF-2-alpha kinase GCN2
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit 1
8894  EIF2S2; eukaryotic translation initiation factor 2 subunit 2 isoform 1
1968  EIF2S3; eukaryotic translation initiation factor 2 subunit 3
1967  EIF2B1; translation initiation factor eIF2B subunit alpha
8892  EIF2B2; translation initiation factor eIF2B subunit beta
8891  EIF2B3; translation initiation factor eIF2B subunit gamma isoform 1
8890  EIF2B4; translation initiation factor eIF2B subunit delta isoform 2
8893  EIF2B5; translation initiation factor eIF2B subunit epsilon
Metabolite
C00009  Orthophosphate
C00035  GDP
Reference
PMID:31201334
  Authors
Gordiyenko Y, Llacer JL, Ramakrishnan V
  Title
Structural basis for the inhibition of translation through eIF2alpha phosphorylation.
  Journal
Nat Commun 10:2640 (2019)
DOI:10.1038/s41467-019-10606-1
Reference
PMID:35568791
  Authors
Yerlikaya A
  Title
Heme-regulated inhibitor: an overlooked eIF2alpha kinase in cancer investigations.
  Journal
Med Oncol 39:73 (2022)
DOI:10.1007/s12032-022-01668-1
Reference
PMID:26636041
  Authors
Holcik M
  Title
Could the eIF2alpha-Independent Translation Be the Achilles Heel of Cancer?
  Journal
Front Oncol 5:264 (2015)
DOI:10.3389/fonc.2015.00264
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