KEGG   REACTION: R01699
Entry
R01699                      Reaction                               

Name
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Definition
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
Equation
Comment
pyruvate dehydrogenase complex: pyruvate dehydrogenase
a part of multi-step reaction (see R00209, R01699+R02569+R07618)
subsequently R02569
TPP-dependent enzyme (see R00014+R03270)
Reaction class
RC00627  C15972_C16255
Enzyme
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
Other DBs
RHEA: 19192
LinkDB

KEGG   REACTION: R02569
Entry
R02569                      Reaction                               

Name
acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase
Definition
Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Equation
Comment
pyruvate dehydrogenase complex:dihydrolipoyllysine-residue acetyltransferase
a part of multi-step reaction (see R00209, R01699+R02569+R07618)
following after R01699
Reaction class
RC00004  C00010_C00024  C15973_C16255
RC02857  C00024_C16255
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
Module
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00627  pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]
Other DBs
RHEA: 17020
LinkDB

KEGG   REACTION: R07618
Entry
R07618                      Reaction                               

Name
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Definition
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
Equation
Comment
Oxo-acid dehydrogenase complexes, dihydrolipoyl dehydrogenase
Reaction class
RC00001  C00003_C00004
RC00583  C15972_C15973
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00280  Valine, leucine and isoleucine degradation
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Orthology
K00382  dihydrolipoamide dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048
LinkDB

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