KEGG   REACTION: R01934
Entry
R01934                      Reaction                               
Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
C05662 + C00003 <=> C00322 + C00011 + C00004 + C00080
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87
     R01934  Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
    1.1.1.286
     R01934  Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
DOI:10.1021/bi00835a023
Other DBs
RHEA: 11903
LinkDB

KEGG   RCLASS: RC00114
Entry
RC00114                     RClass                                 
Definition
C1b-C1c:*-C6a:C1b+C5a-C1b+C1c
C5a-C1c:*-*:C1b+C6a+O5a-C1c+C6a+O1a
Reactant pair
C00026_C00311    C00322_C05662    C16588_C16597
C16589_C16600    C17211_C17212    C17215_C17216
C17219_C17220    C17223_C17224    C17227_C17228
C17231_C17232    C17948_C21372    C20327_C20654
Related class
Reaction
R00267 R00709 R01934 R08214 R08215 R08621 R08625 R08629
R08636 R08642 R08646 R08888 R10502
Enzyme
1.1.1.41        1.1.1.42        1.1.1.87        1.1.1.286       
1.1.1.-
Pathway
rn00020  Citrate cycle (TCA cycle)
rn00300  Lysine biosynthesis
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00680  Methane metabolism
rn00720  Other carbon fixation pathways
rn00966  Glucosinolate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K00030  isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17750  3-benzylmalate dehydrogenase [EC:1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]

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