KEGG   REACTION: R07969
Entry
R07969                      Reaction                               
Name
1-methylxanthine:oxygen oxidoreductase (N1-demethylating)
Definition
1-Methylxanthine + NADH + H+ + Oxygen <=> Xanthine + NAD+ + Formaldehyde + H2O
Equation
C16358 + C00004 + C00080 + C00007 <=> C00385 + C00003 + C00067 + C00001
Reaction class
RC00001  C00003_C00004
RC00334  C00385_C16358
RC01797  C00067_C16358
Enzyme
1.14.13.178
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.178
     R07969  1-Methylxanthine + NADH + H+ + Oxygen <=> Xanthine + NAD+ + Formaldehyde + H2O
Orthology
K21722  methylxanthine N1-demethylase [EC:1.14.13.178]
LinkDB

KEGG   REACTION: R07970
Entry
R07970                      Reaction                               
Name
1-methylxanthine:oxygen oxidoreductase (N1-demethylating)
Definition
1-Methylxanthine + NADPH + H+ + Oxygen <=> Xanthine + NADP+ + Formaldehyde + H2O
Equation
C16358 + C00005 + C00080 + C00007 <=> C00385 + C00006 + C00067 + C00001
Reaction class
RC00001  C00005_C00006
RC00334  C00385_C16358
RC01797  C00067_C16358
Enzyme
1.14.13.178
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.178
     R07970  1-Methylxanthine + NADPH + H+ + Oxygen <=> Xanthine + NADP+ + Formaldehyde + H2O
Orthology
K21722  methylxanthine N1-demethylase [EC:1.14.13.178]
LinkDB

KEGG   RCLASS: RC00334
Entry
RC00334                     RClass                                 
Definition
N4x-N4y:*-C1a:C8y+C8y-C8y+C8y
Reactant pair
C00385_C16357    C00385_C16358    C01977_C04157
C07130_C16357    C07130_C16358    C07480_C07481
C07480_C16353    C07481_C13747    C13747_C16353
C20649_C20652    C21956_C21957
Related class
Reaction
R00597 R07919 R07920 R07921 R07922 R07939 R07954 R07955
R07956 R07957 R07958 R07961 R07962 R07967 R07968 R07969
R07970 R07973 R07974 R07975 R07976 R10498 R12157
Enzyme
1.14.13.178     1.14.13.179     1.14.14.1       2.1.1.159       
2.1.1.160       2.1.1.228       2.1.1.282       2.1.1.349
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K00554  tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K12730  theobromine synthase [EC:2.1.1.159]
K12731  caffeine synthase [EC:2.1.1.160]
K15429  tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K20331  toxoflavin synthase [EC:2.1.1.349]
K21722  methylxanthine N1-demethylase [EC:1.14.13.178]
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]

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