KEGG   REACTION: R08527
Entry
R08527                      Reaction                               
Name
arachidonate 5-lipoxygenase
Definition
Arachidonate + Oxygen <=> Leukotriene A4 + H2O
Equation
C00219 + C00007 <=> C00909 + C00001
Comment
two-step reaction (R01595+R03058)
Reaction class
RC02139  C00219_C00909
Enzyme
1.13.11.34
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34
     R08527  Arachidonate + Oxygen <=> Leukotriene A4 + H2O
Orthology
K00461  arachidonate 5-lipoxygenase [EC:1.13.11.34]
Other DBs
RHEA: 32310
LinkDB

KEGG   REACTION: R01595
Entry
R01595                      Reaction                               
Name
arachidonate:oxygen 5-oxidoreductase
Definition
Arachidonate + Oxygen <=> 5(S)-HPETE
Equation
C00219 + C00007 <=> C05356
Comment
the first step of two-step reaction (see R08527, R01595+R03058)
subsequently R03058
Reaction class
RC00561  C00219_C05356
Enzyme
1.13.11.34
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34
     R01595  Arachidonate + Oxygen <=> 5(S)-HPETE
Orthology
K00461  arachidonate 5-lipoxygenase [EC:1.13.11.34]
Other DBs
RHEA: 17488
LinkDB

KEGG   REACTION: R03058
Entry
R03058                      Reaction                               
Name
arachidonate:oxygen 5-oxidoreductase
Definition
5(S)-HPETE <=> Leukotriene A4 + H2O
Equation
C05356 <=> C00909 + C00001
Comment
the second step of two-step reaction (see R08527, R01595+R03058)
following after R01595
Reaction class
RC00839  C00909_C05356
Enzyme
1.13.11.34
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34
     R03058  5(S)-HPETE <=> Leukotriene A4 + H2O
Orthology
K00461  arachidonate 5-lipoxygenase [EC:1.13.11.34]
Other DBs
RHEA: 17964
LinkDB

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