KEGG   REACTION: R08549
Entry
R08549                      Reaction                               
Name
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating);
2-oxoglutarate dehydrogenase complex
Definition
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
Equation
C00026 + C00010 + C00003 <=> C00091 + C00011 + C00004 + C00080
Comment
multienzyme system: ec 1.2.4.2, ec 2.3.1.61 and ec 1.8.1.4
multi-step reaction (see R01700+R02570+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00091
RC02833  C00026_C00091
Enzyme
1.2.1.105
Pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
Orthology
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00658  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
Other DBs
RHEA: 27789
LinkDB

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