REACTION: R08642
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Entry
R08642 Reaction
Name
3-(6'-methylthio)hexylmalate:NAD+ oxidoreductase (decarboxylating)
Definition
3-(6'-Methylthio)hexylmalic acid + NAD+ <=> 2-Oxo-9-methylthiononanoic acid + CO2 + NADH + H+
Equation
C17227
+
C00003
<=>
C17228
+
C00011
+
C00004
+
C00080
Comment
two-step reaction (similar to
R10052, R04426+R01652
)
Reaction class
RC00114
C17227_C17228
Enzyme
1.1.1.-
Pathway
rn00966
Glucosinolate biosynthesis
rn01210
2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.-
R08642 3-(6'-Methylthio)hexylmalic acid + NAD+ <=> 2-Oxo-9-methylthiononanoic acid + CO2 + NADH + H+
BRITE hierarchy
Orthology
K21360
3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:
1.1.1.85
1.1.1.-]
LinkDB
All DBs
RCLASS: RC00114
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Entry
RC00114 RClass
Definition
C1b-C1c:*-C6a:C1b+C5a-C1b+C1c
C5a-C1c:*-*:C1b+C6a+O5a-C1c+C6a+O1a
Reactant pair
C00026_C00311
C00322_C05662
C16588_C16597
C16589_C16600
C17211_C17212
C17215_C17216
C17219_C17220
C17223_C17224
C17227_C17228
C17231_C17232
C17948_C21372
C20327_C20654
Related class
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Reaction
R00267
R00709
R01934
R08214
R08215
R08621
R08625
R08629
R08636
R08642
R08646
R08888
R10502
Enzyme
1.1.1.41
1.1.1.42
1.1.1.87
1.1.1.286
1.1.1.-
Pathway
rn00020
Citrate cycle (TCA cycle)
rn00300
Lysine biosynthesis
rn00400
Phenylalanine, tyrosine and tryptophan biosynthesis
rn00440
Phosphonate and phosphinate metabolism
rn00680
Methane metabolism
rn00720
Other carbon fixation pathways
rn00966
Glucosinolate biosynthesis
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
rn01120
Microbial metabolism in diverse environments
rn01200
Carbon metabolism
rn01210
2-Oxocarboxylic acid metabolism
rn01230
Biosynthesis of amino acids
rn01240
Biosynthesis of cofactors
RModule
RM001
2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K00030
isocitrate dehydrogenase (NAD+) [EC:
1.1.1.41
]
K00031
isocitrate dehydrogenase [EC:
1.1.1.42
]
K05824
homoisocitrate dehydrogenase [EC:
1.1.1.87
]
K10978
methanogen homoisocitrate dehydrogenase [EC:
1.1.1.87
1.1.1.-]
K17750
3-benzylmalate dehydrogenase [EC:1.1.1.-]
K17753
isocitrate--homoisocitrate dehydrogenase [EC:
1.1.1.286
]
K21360
3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:
1.1.1.85
1.1.1.-]
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integrated database retrieval system