KEGG REACTION: R08764

REACTION: R08764

Entry

R08764                      Reaction

Name

6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)

Definition

6-Hydroxynicotinate + NADH + Oxygen + H+ <=> 2,5-Dihydroxypyridine + NAD+ + CO2 + H2O

Equation

C01020 + C00004 + C00007 + C00080 <=> C01059 + C00003 + C00011 + C00001

Reaction class

RC00001

C00003_C00004

RC00115

C01020_C01059

Enzyme

1.14.13.114

Pathway

rn00760

Nicotinate and nicotinamide metabolism

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

Module

M00622

Nicotinate degradation, nicotinate => fumarate

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.114
     R08764  6-Hydroxynicotinate + NADH + Oxygen + H+ <=> 2,5-Dihydroxypyridine + NAD+ + CO2 + H2O

Orthology

K14974

6-hydroxynicotinate 3-monooxygenase [EC:1.14.13.114]

Reference

1 [PMID:10091591]

Authors

Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T

Title

Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.

Journal

Eur J Biochem 260:120-6 (1999)
DOI:10.1046/j.1432-1327.1999.00124.x

Other DBs

RHEA:

27336

LinkDB

RCLASS: RC00115

Entry

RC00115                     RClass

Definition

C8y-C8y:C6a+*-*+O1a:C8x+C8x-C8x+C8x

Reactant pair

C00156_C00530 C00230_C02814 C00568_C02372
C01020_C01059 C10793_C18131

Related class

Reaction

R00047 R01297 R01299 R01629 R01630 R02561 R02562 R08764
R09041

Enzyme

1.14.13.27 1.14.13.64 1.14.13.114 1.14.99.-

Pathway

rn00130

Ubiquinone and other terpenoid-quinone biosynthesis

rn00362

Benzoate degradation

rn00627

Aminobenzoate degradation