KEGG   PATHWAY: aalb03015
Entry
aalb03015                   Pathway                                
Name
mRNA surveillance pathway - Aedes albopictus (Asian tiger mosquito)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
aalb03015  mRNA surveillance pathway
aalb03015

Other DBs
GO: 0071028
Organism
Aedes albopictus (Asian tiger mosquito) [GN:aalb]
Gene
109427984  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like [KO:K12882]
115268730  nuclear cap-binding protein subunit 1-like [KO:K12882]
115268732  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like [KO:K12882]
109413671  nuclear cap-binding protein subunit 2 [KO:K12883]
109428707  regulator of nonsense transcripts 3B [KO:K14328]
109426594  RNA-binding protein 8A [KO:K12876]
109412057  protein mago nashi [KO:K12877]
109405422  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109402421  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
115256192  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
115269180  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
109430469  histone deacetylase complex subunit SAP18-like [KO:K14324]
115268465  histone deacetylase complex subunit SAP18-like [KO:K14324]
115268509  histone deacetylase complex subunit SAP18-like [KO:K14324]
109405953  pinin [KO:K13114]
109417114  LOW QUALITY PROTEIN: pinin-like [KO:K13114]
109423912  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109404786  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
109408287  RNA-binding protein with serine-rich domain 1-A [KO:K14325]
109409539  THO complex subunit 4-like [KO:K12881]
109426403  THO complex subunit 4-like [KO:K12881]
109398022  THO complex subunit 4 [KO:K12881]
109399955  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
109622242  nucleoporin GLE1 [KO:K18723]
109427121  nuclear RNA export factor 2 [KO:K14284]
109418413  nuclear RNA export factor 1-like [KO:K14284]
109400194  nuclear RNA export factor 2-like [KO:K14284]
109426144  LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
115254101  nuclear RNA export factor 1-like [KO:K14284]
109402269  NTF2-related export protein [KO:K14285]
109421659  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
109402590  partner of Y14 and mago [KO:K14294]
109431612  mRNA-capping enzyme-like [KO:K13917] [EC:2.7.7.50 3.6.1.74]
109432065  mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
109402413  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
109405455  LOW QUALITY PROTEIN: RNA-binding protein cabeza-like [KO:K13098]
115253590  RNA-binding protein cabeza-like [KO:K13098]
115260811  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
109427540  TAR DNA-binding protein 43-like isoform X2 [KO:K23600]
115256405  TAR DNA-binding protein 43-like [KO:K23600]
115256680  TAR DNA-binding protein 43-like isoform X1 [KO:K23600]
109405147  polyadenylate-binding protein 2 [KO:K14396]
109413505  cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
109404945  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
109431672  cleavage and polyadenylation specificity factor subunit CG7185 isoform X1 [KO:K14398]
109419129  poly(A) polymerase type 3 [KO:K14376] [EC:2.7.7.19]
115259937  LOW QUALITY PROTEIN: poly(A) polymerase type 3-like [KO:K14376] [EC:2.7.7.19]
109409346  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
109418256  uncharacterized protein LOC109418256 isoform X1 [KO:K14400]
109408986  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 1-like [KO:K14401]
109621621  LOW QUALITY PROTEIN: probable cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
109400054  LOW QUALITY PROTEIN: probable cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
115254360  probable cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
109404703  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor 73 [KO:K14403] [EC:3.1.27.-]
109407071  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 4-like [KO:K14404]
109411896  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 4-like [KO:K14404]
109405023  LOW QUALITY PROTEIN: pre-mRNA 3' end processing protein WDR33 [KO:K15542]
109622053  pre-mRNA 3' end processing protein WDR33 [KO:K15542]
109418092  WD repeat-containing protein 82 [KO:K14962]
109418363  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109426122  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109412802  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
109418407  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109421935  RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like [KO:K15544] [EC:3.1.3.16]
109418331  LOW QUALITY PROTEIN: cleavage stimulation factor subunit 1-like [KO:K14406]
109427300  cleavage stimulation factor subunit 1 [KO:K14406]
109432374  LOW QUALITY PROTEIN: cleavage stimulation factor subunit 2 tau variant-like [KO:K14407]
109423070  cleavage stimulation factor subunit 2 tau variant [KO:K14407]
115254034  cleavage stimulation factor subunit 2 tau variant-like [KO:K14407]
109422773  protein suppressor of forked-like [KO:K14408]
115260625  LOW QUALITY PROTEIN: protein suppressor of forked-like [KO:K14408]
109622351  LOW QUALITY PROTEIN: symplekin [KO:K06100]
109406697  symplekin [KO:K06100]
109418888  RNA-binding protein Musashi homolog Rbp6-like [KO:K14411]
109426368  heterogeneous nuclear ribonucleoprotein 27C [KO:K14411]
109400186  RNA-binding protein Musashi homolog 2-like isoform X1 [KO:K14411]
109427106  RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
115253927  heterogeneous nuclear ribonucleoprotein 27C-like [KO:K14411]
115253732  RNA-binding protein Musashi homolog Rbp6-like [KO:K14411]
109407505  polyadenylate-binding protein 4-like [KO:K13126]
109425762  LOW QUALITY PROTEIN: polyadenylate-binding protein 4-like [KO:K13126]
109407548  polyadenylate-binding protein 1 [KO:K13126]
109430796  polyadenylate-binding protein 1 [KO:K13126]
109413559  eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
109407899  eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
109423943  LOW QUALITY PROTEIN: eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
109430988  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
115265634  eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like isoform X1 [KO:K03267]
109405747  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
109406901  LOW QUALITY PROTEIN: regulator of nonsense transcripts 2 [KO:K14327]
115267134  LOW QUALITY PROTEIN: regulator of nonsense transcripts 2-like [KO:K14327]
109427666  LOW QUALITY PROTEIN: serine/threonine-protein kinase Smg1 [KO:K08873] [EC:2.7.11.1]
115260732  serine/threonine-protein kinase Smg1-like isoform X1 [KO:K08873] [EC:2.7.11.1]
109415051  protein SMG5 [KO:K11125]
109621961  protein SMG5-like [KO:K11125]
109431117  LOW QUALITY PROTEIN: uncharacterized protein LOC109431117 [KO:K11124] [EC:3.1.-.-]
109424979  telomerase-binding protein EST1A-like [KO:K11124] [EC:3.1.-.-]
109420084  serine/threonine-protein phosphatase PP2A [KO:K04382] [EC:3.1.3.16]
109431326  serine/threonine-protein phosphatase PP2A-like [KO:K04382] [EC:3.1.3.16]
109430154  serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit [KO:K03456]
115261019  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit-like [KO:K03456]
109400400  protein phosphatase PP2A 55 kDa regulatory subunit isoform X3 [KO:K04354]
109426187  uncharacterized protein LOC109426187 isoform X1 [KO:K11583]
109418457  LOW QUALITY PROTEIN: uncharacterized protein LOC109418457 [KO:K11583]
109406521  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
109429667  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
109399839  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
109425375  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
115262115  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
115269073  HBS1-like protein [KO:K14416]
115269506  HBS1-like protein [KO:K14416]
109429955  protein pelota [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
aalb03013  Nucleocytoplasmic transport
aalb03018  RNA degradation
aalb03040  Spliceosome
KO pathway
ko03015   
LinkDB

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