KEGG   PATHWAY: acun03013
Entry
acun03013                   Pathway                                
Name
Nucleocytoplasmic transport - Athene cunicularia (burrowing owl)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
acun03013  Nucleocytoplasmic transport
acun03013

Other DBs
GO: 0050658
Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113475850  NUP37; nucleoporin Nup37 [KO:K14302]
113475865  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
113475874  TNPO3; transportin-3 [KO:K15436]
113476003  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
113476099  SEH1L; nucleoporin SEH1 [KO:K14299]
113476115  THOC1; THO complex subunit 1 [KO:K12878]
113476274  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
113477010  NUPL2; nucleoporin-like protein 2 [KO:K14321]
113477612  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
113477629  AHCTF1; protein ELYS [KO:K25129]
113477759  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
113477875  NUP43; nucleoporin Nup43 [KO:K14305]
113478005  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
113478040  XPO5; exportin-5 [KO:K14289]
113478097  XPO1; exportin-1 [KO:K14290]
113478162  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
113479087  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
113479745  IPO5; importin-5 [KO:K20222]
113479816  NUP54; nucleoporin p54 [KO:K14308]
113479926  NXT2; NTF2-related export protein 2 [KO:K14285]
113480080  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
113480129  KPNA3; importin subunit alpha-4 [KO:K23583]
113480146  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
113480147  THOC2; THO complex subunit 2 [KO:K12879]
113480224  [KO:K12883]
113480475  PNN; pinin [KO:K13114]
113481002  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
113481342  IPO7; importin-7 [KO:K20223]
113481478  XPO4; exportin-4 [KO:K25203]
113482073  [KO:K14313]
113482074  [KO:K14313]
113482563  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
113482699  IPO13; importin-13 [KO:K25202]
113482765  NDC1; nucleoporin NDC1 [KO:K14315]
113482801  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
113483251  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
113483277  KPNA4; importin subunit alpha-3 [KO:K23583]
113483455  [KO:K12883]
113483651  [KO:K12160]
113483744  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
113484153  SNUPN; snurportin-1 [KO:K13151]
113484307  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
113484769  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
113484846  SEC13; protein SEC13 homolog [KO:K14004]
113484914  THOC7; THO complex subunit 7 homolog [KO:K13176]
113484938  [KO:K14314]
113485084  THOC3; THO complex subunit 3 [KO:K12880]
113485187  RANBP17; ran-binding protein 17 [KO:K24115]
113485334  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
113485575  NUP58; nucleoporin p58/p45 [KO:K14307]
113485637  XPO6; exportin-6 isoform X1 [KO:K25204]
113485825  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
113485843  KPNA7; importin subunit alpha-8 [KO:K15043]
113485901  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
113486002  RAN; GTP-binding nuclear protein Ran [KO:K07936]
113486163  THOC5; THO complex subunit 5 homolog [KO:K13174]
113486376  NUP188; nucleoporin NUP188 homolog [KO:K14311]
113486544  GLE1; nucleoporin GLE1 [KO:K18723]
113486598  NUP214; nuclear pore complex protein Nup214 [KO:K14317]
113486715  KPNA1; importin subunit alpha-5 [KO:K23940]
113486717  KPNA2; importin subunit alpha-1 [KO:K15043]
113486936  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
113486937  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
113486983  ALYREF; THO complex subunit 4 [KO:K12881]
113487038  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
113487358  [KO:K14316]
113487382  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
113487404  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
113487470  CSE1L; exportin-2 [KO:K18423]
113487503  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
113487548  RAE1; mRNA export factor isoform X1 [KO:K14298]
113487810  [KO:K18655] [EC:5.6.2.7]
113488080  XPO7; exportin-7 [KO:K18460]
113488146  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
113488284  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
113488995  IPO9; importin-9 [KO:K20224]
113489302  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
113489718  IPO11; importin-11 [KO:K25201]
113489781  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
113490071  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
113490342  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
113490354  TNPO1; transportin-1 [KO:K18752]
113490688  AAAS; aladin isoform X1 [KO:K14320]
113490798  KPNB1; importin subunit beta-1 [KO:K14293]
113491085  XPOT; exportin-T [KO:K14288]
113491142  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
113491365  IPO8; importin-8 isoform X1 [KO:K18755]
113491389  NUP205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
113491410  RGPD4; ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
acun03015  mRNA surveillance pathway
KO pathway
ko03013   

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