KEGG   PATHWAY: ajm03013
Entry
ajm03013                    Pathway                                
Name
Nucleocytoplasmic transport - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ajm03013  Nucleocytoplasmic transport
ajm03013

Other DBs
GO: 0050658
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119035118  KPNA4; importin subunit alpha-3 [KO:K23583]
119035818  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
119036214  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
119036343  KPNA2; importin subunit alpha-1 [KO:K15043]
119037005  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
119037212  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
119037289  IPO4; importin-4 isoform X1 [KO:K20221]
119037500  CASC3; protein CASC3 isoform X2 [KO:K14323]
119038329  SEC13; protein SEC13 homolog isoform X2 [KO:K14004]
119038488  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
119038504  SNUPN; snurportin-1 isoform X2 [KO:K13151]
119038748  SENP2; sentrin-specific protease 2 isoform X2 [KO:K03345] [EC:3.4.22.68]
119039138  POM121L2; POM121-like protein 2 [KO:K14316]
119039625  KPNA1; importin subunit alpha-5 [KO:K23940]
119040634  RAE1; mRNA export factor RAE1 [KO:K14298]
119040723  IPO7; importin-7 isoform X1 [KO:K20223]
119042149  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
119042184  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
119042399  THOC7; THO complex subunit 7 homolog [KO:K13176]
119042433  IPO11; importin-11 isoform X1 [KO:K25201]
119042564  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
119042916  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
119043244  NUP58; nucleoporin p58/p45 [KO:K14307]
119043514  AAAS; aladin isoform X1 [KO:K14320]
119043904  TMEM33; transmembrane protein 33 [KO:K20724]
119044003  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
119044132  [KO:K12172] [EC:2.3.2.-]
119044306  [KO:K03231]
119044461  AHCTF1; protein ELYS [KO:K25129]
119045114  IPO8; importin-8 [KO:K18755]
119045352  XPO6; exportin-6 isoform X1 [KO:K25204]
119045483  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
119045545  XPOT; exportin-T isoform X1 [KO:K14288]
119045921  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
119046050  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
119046093  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
119046096  [KO:K14284]
119046430  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
119046853  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119048516  NUP133; nuclear pore complex protein Nup133 isoform X2 [KO:K14300]
119048543  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
119048606  NUP88; nuclear pore complex protein Nup88 isoform X2 [KO:K14318]
119049413  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
119049436  NXT2; NTF2-related export protein 2 [KO:K14285]
119049455  [KO:K12877]
119049636  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
119049648  TNPO2; transportin-2 isoform X1 [KO:K18727]
119050612  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
119050754  NUP188; nucleoporin NUP188 [KO:K14311]
119050843  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
119050913  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
119051262  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
119051570  NXT1; NTF2-related export protein 1 [KO:K14285]
119051765  THOC3; THO complex subunit 3 isoform X1 [KO:K12880]
119052081  TNPO1; transportin-1 isoform X2 [KO:K18752]
119052258  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
119052316  IPO13; importin-13 [KO:K25202]
119052591  KPNB1; importin subunit beta-1 [KO:K14293]
119052820  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
119052998  GLE1; mRNA export factor GLE1 [KO:K18723]
119053712  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
119054665  XPO7; exportin-7 [KO:K18460]
119055133  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
119055270  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
119055376  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
119055598  XPO5; exportin-5 isoform X1 [KO:K14289]
119055830  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
119055839  THOC2; THO complex subunit 2 isoform X2 [KO:K12879]
119055873  [KO:K18655] [EC:5.6.2.7]
119055878  [KO:K18655] [EC:5.6.2.7]
119056200  IPO5; importin-5 [KO:K20222]
119056248  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
119056344  [KO:K14316]
119056676  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
119057871  NUP43; nucleoporin Nup43 [KO:K14305]
119058198  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
119058233  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
119058473  XPO4; exportin-4 isoform X1 [KO:K25203]
119058506  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
119058565  ALYREF; THO complex subunit 4 [KO:K12881]
119058622  SUMO2; small ubiquitin-related modifier 2 isoform X2 [KO:K12160]
119058633  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
119058647  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119058721  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
119058758  [KO:K12160]
119058773  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
119058901  THOC1; THO complex subunit 1 [KO:K12878]
119059007  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
119059297  PNN; pinin [KO:K13114]
119059346  [KO:K12160]
119059622  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
119060101  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
119060179  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
119060266  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
119060506  NUP37; nucleoporin Nup37 [KO:K14302]
119060748  IPO9; importin-9 isoform X1 [KO:K20224]
119060801  RAN; GTP-binding nuclear protein Ran [KO:K07936]
119061313  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
119061373  MAGOH; protein mago nashi homolog [KO:K12877]
119061795  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
119062647  XPO1; exportin-1 [KO:K14290]
119062963  KPNA7; importin subunit alpha-8 [KO:K15043]
119063234  CSE1L; exportin-2 [KO:K18423]
119063480  [KO:K12877]
119063518  [KO:K12879]
119063831  [KO:K12160]
119064239  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
119064461  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
119065175  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
119065380  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
119065653  TNPO3; transportin-3 isoform X1 [KO:K15436]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ajm03015  mRNA surveillance pathway
KO pathway
ko03013   

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