KEGG   PATHWAY: alca00290
Entry
alca00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Alcanivorax sp. ALC70
Class
Metabolism; Amino acid metabolism
Pathway map
alca00290  Valine, leucine and isoleucine biosynthesis
alca00290

Module
alca_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:alca00290]
alca_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:alca00290]
alca_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:alca00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Alcanivorax sp. ALC70 [GN:alca]
Gene
ASALC70_00912  budB; Acetolactate synthase, catabolic [KO:K01652] [EC:2.2.1.6]
ASALC70_01372  ilvC; Ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
ASALC70_01380  ilvH; Acetolactate synthase isozyme 3 small subunit [KO:K01653] [EC:2.2.1.6]
ASALC70_01382  ilvI_2; Acetolactate synthase isozyme 3 large subunit [KO:K01652] [EC:2.2.1.6]
ASALC70_01653  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
ASALC70_02087  ilvA_2; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
ASALC70_02779  ilvD_1; Dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
ASALC70_02796  ilvD_2; Dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
ASALC70_02803  ilvE_1; Branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
ASALC70_04193  alaA; Glutamate-pyruvate aminotransferase AlaA [KO:K14260] [EC:2.6.1.66 2.6.1.2]
ASALC70_04223  ilvB1; Acetolactate synthase large subunit IlvB1 [KO:K01652] [EC:2.2.1.6]
ASALC70_04313  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
ASALC70_04314  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
ASALC70_04315  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
alca00260  Glycine, serine and threonine metabolism
alca00280  Valine, leucine and isoleucine degradation
alca00620  Pyruvate metabolism
KO pathway
ko00290   

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