KEGG   PATHWAY: alca00260
Entry
alca00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Alcanivorax sp. ALC70
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
alca00260  Glycine, serine and threonine metabolism
alca00260

Module
alca_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:alca00260]
alca_M00621  Glycine cleavage system [PATH:alca00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Alcanivorax sp. ALC70 [GN:alca]
Gene
ASALC70_00049  thrH_2; Phosphoserine phosphatase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
ASALC70_00238  ectD_1; Ectoine dioxygenase [KO:K10674] [EC:1.14.11.55]
ASALC70_00254  betB_1; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ASALC70_00706  [KO:K00928] [EC:2.7.2.4]
ASALC70_00827  serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ASALC70_01371  [KO:K17103] [EC:2.7.8.8]
ASALC70_02062  gcvPB_2; putative glycine dehydrogenase (decarboxylating) subunit 2 [KO:K00283] [EC:1.4.4.2]
ASALC70_02063  gcvPA; putative glycine dehydrogenase (decarboxylating) subunit 1 [KO:K00282] [EC:1.4.4.2]
ASALC70_02064  gcvH; Glycine cleavage system H protein [KO:K02437]
ASALC70_02065  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ASALC70_02087  ilvA_2; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
ASALC70_02110  [KO:K18896] [EC:2.1.1.156]
ASALC70_02111  [KO:K18897] [EC:2.1.1.157]
ASALC70_02204  doeB_2; N-alpha-acetyl-L-2,4-diaminobutyric acid deacetylase [KO:K15784] [EC:3.5.1.125]
ASALC70_02358  serA_2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ASALC70_02490  thrB; Homoserine kinase [KO:K02204] [EC:2.7.1.39]
ASALC70_02515  ectD_2; Ectoine dioxygenase [KO:K10674] [EC:1.14.11.55]
ASALC70_02650  betB_3; NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ASALC70_02652  [KO:K00018] [EC:1.1.1.29]
ASALC70_02864  ttuD_2; Putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
ASALC70_02912  [KO:K01079] [EC:3.1.3.3]
ASALC70_02984  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ASALC70_03118  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
ASALC70_03120  ectB_2; Diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
ASALC70_03655  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ASALC70_04123  gpmA_2; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
ASALC70_04150  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
ASALC70_04281  lpd_2; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ASALC70_04316  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ASALC70_04317  asd2; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
ASALC70_04322  trpB_1; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
ASALC70_04323  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ASALC70_04427  trpB_2; Tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
alca00010  Glycolysis / Gluconeogenesis
alca00020  Citrate cycle (TCA cycle)
alca00230  Purine metabolism
alca00250  Alanine, aspartate and glutamate metabolism
alca00270  Cysteine and methionine metabolism
alca00290  Valine, leucine and isoleucine biosynthesis
alca00300  Lysine biosynthesis
alca00330  Arginine and proline metabolism
alca00460  Cyanoamino acid metabolism
alca00470  D-Amino acid metabolism
alca00564  Glycerophospholipid metabolism
alca00620  Pyruvate metabolism
alca00630  Glyoxylate and dicarboxylate metabolism
alca00640  Propanoate metabolism
alca00680  Methane metabolism
alca00860  Porphyrin metabolism
alca00920  Sulfur metabolism
KO pathway
ko00260   

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