Entry
Name
Biosynthesis of type II polyketide backbone - Amycolatopsis mediterranei U32
Class
Metabolism; Metabolism of terpenoids and polyketides
BRITE hierarchy
Pathway map
amd01056 Biosynthesis of type II polyketide backbone
Organism
Amycolatopsis mediterranei U32 [GN:
amd ]
Gene
Compound
C12348 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp]
C12350 3,5,7,9,11,13,15-Heptaoxo-octadecanoyl-[acp]
C12354 3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp]
C12355 3,5,7,9,11,13,15,17,19-Nonaoxo-henicosanoyl-[acp]
C12356 3,5,7,9,11,13,15,17,19-Nonaoxo-docosanoyl-[acp]
C12441 18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp]
C12442 C-9 Reduced nonaketamide
C18293 Nonaketamide monocyclic intermediate
C18327 7,9,12-Octaketide intermediate 1
C18328 7,9,12-Octaketide intermediate 2
C18329 7,9,12-Octaketide intermediate 3
C18330 7,9,12-Decaketide intermediate 1
C18331 7,9,12-Decaketide intermediate 2
C18332 7,9,12-Decaketide intermediate 3
C18333 7,9,12-Decaketide intermediate 4
C18334 7,9,12-Decaketide intermediate 5
C18335 7,9,12-Decaketide intermediate 6
C18336 7,12-Decaketide intermediate 1
C18337 9,14-Decaketide intermediate 1
C21430 Malonamoyl-[acyl-carrier protein]
Reference
Authors
Rawlings BJ
Title
Biosynthesis of polyketides (other than actinomycete macrolides).
Journal
Reference
Authors
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A
Title
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
Journal
Reference
Authors
Moore BS, Hertweck C
Title
Biosynthesis and attachment of novel bacterial polyketide synthase starter units.
Journal
Reference
Authors
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM
Title
An antibiotic factory caught in action.
Journal
Reference
Authors
Ridley CP, Lee HY, Khosla C
Title
Evolution of polyketide synthases in bacteria.
Journal
Reference
Authors
Pickens LB, Tang Y
Title
Oxytetracycline biosynthesis.
Journal
Reference
Authors
Petkovic H, Thamchaipenet A, Zhou LH, Hranueli D, Raspor P, Waterman PG, Hunter IS
Title
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.
Journal
Reference
Authors
Zhou H, Li Y, Tang Y
Title
Cyclization of aromatic polyketides from bacteria and fungi.
Journal
Reference
Authors
Korman TP, Tan YH, Wong J, Luo R, Tsai SC
Title
Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase.
Journal
Reference
Authors
Kantola J, Blanco G, Hautala A, Kunnari T, Hakala J, Mendez C, Ylihonko K, Mantsala P, Salas J
Title
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.
Journal
Reference
Authors
Kunnari T, Ylihonko K, Hautala A, Klika KD, Mantsala P, Hakala J
Title
Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.
Journal
Reference
Authors
Tsai SC, Ames BD
Title
Structural enzymology of polyketide synthases.
Journal
Reference
Authors
Korman TP, Hill JA, Vu TN, Tsai SC
Title
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.
Journal
Reference
Authors
Hadfield AT, Limpkin C, Teartasin W, Simpson TJ, Crosby J, Crump MP
Title
The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.
Journal
Reference
Authors
Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P
Title
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
Journal
Reference
Authors
Bartel PL, Zhu CB, Lampel JS, Dosch DC, Connors NC, Strohl WR, Beale JM Jr, Floss HG
Title
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions.
Journal
Reference
Authors
Arthur CJ, Szafranska AE, Long J, Mills J, Cox RJ, Findlow SC, Simpson TJ, Crump MP, Crosby J
Title
The malonyl transferase activity of type II polyketide synthase acyl carrier proteins.
Journal
Reference
Authors
Schneider G
Title
Enzymes in the biosynthesis of aromatic polyketide antibiotics.
Journal
Reference
Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
Title
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
Journal
Reference
Authors
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC
Title
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
Journal
Reference
Authors
Lombo F, Menendez N, Salas JA, Mendez C
Title
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.
Journal
Reference
Authors
Krohn K (ed).
Title
Anthracycline Chemistry and Biology I : Biological Occurence and Biosynthesis, Synthesis and Chemistry
Journal
Topics in Current Chemistry 282 (2008)
Related pathway
amd00280 Valine, leucine and isoleucine degradation
amd01057 Biosynthesis of type II polyketide products
KO pathway