KEGG   PATHWAY: amd00280
Entry
amd00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Amycolatopsis mediterranei U32
Class
Metabolism; Amino acid metabolism
Pathway map
amd00280  Valine, leucine and isoleucine degradation
amd00280

Module
amd_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:amd00280]
amd_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:amd00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Amycolatopsis mediterranei U32 [GN:amd]
Gene
AMED_0274  acsA; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
AMED_0542  paaG; enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
AMED_0746  [KO:K18661] [EC:6.2.1.76 6.2.1.-]
AMED_0881  [KO:K00128] [EC:1.2.1.3]
AMED_0913  [KO:K01847] [EC:5.4.99.2]
AMED_0914  [KO:K01847] [EC:5.4.99.2]
AMED_0934  [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
AMED_0945  [KO:K27095]
AMED_0946  [KO:K27094]
AMED_0975  hmgL; hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
AMED_1196  gabT; 4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
AMED_1401  [KO:K00128] [EC:1.2.1.3]
AMED_1462  hmgL; hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
AMED_1547  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_1577  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
AMED_1578  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMED_1614  paaG; enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
AMED_2169  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMED_2179  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
AMED_2550  atoB; acetyl-CoA C-acetyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_2555  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMED_2631  fadA; acetyl-CoA acyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_2710  mmsB; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
AMED_2886  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_3044  mmsA; methylmalonate-semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
AMED_3140  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_3268  acsA; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
AMED_3369  [KO:K01966] [EC:6.4.1.3 2.1.3.15]
AMED_3382  atoB; acetyl-CoA C-acetyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_3833  [KO:K00128] [EC:1.2.1.3]
AMED_3836  atoB; acetyl-CoA C-acetyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_3839  mmsB; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
AMED_3855  fadA; acetyl-CoA acyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_4613  fadA; acetyl-CoA acyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_4755  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
AMED_6207  mmsB; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
AMED_6573  mmsB; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
AMED_6635  mmsA; methylmalonate-semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
AMED_6666  paaG; enoyl-CoA hydratase [KO:K13766] [EC:4.2.1.18]
AMED_6934  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMED_6955  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMED_6963  [KO:K00271] [EC:1.4.1.23]
AMED_7122  bkdA; 2-oxoisovalerate dehydrogenase E1 component [KO:K11381] [EC:1.2.4.4]
AMED_7134  [KO:K00128] [EC:1.2.1.3]
AMED_7171  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_7190  fadA; acetyl-CoA acyltransferase [KO:K00632] [EC:2.3.1.16]
AMED_7193  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_7200  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMED_7209  [KO:K00128] [EC:1.2.1.3]
AMED_7569  pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [KO:K09699] [EC:2.3.1.168]
AMED_7570  pdhB; pyruvate dehydrogenase E1 component subunit beta [KO:K00167] [EC:1.2.4.4]
AMED_7571  pdhA; pyruvate dehydrogenase E1 component subunit alpha [KO:K00166] [EC:1.2.4.4]
AMED_7893  fadB; 3-hydroxyacyl-CoA dehydrogenase [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
AMED_7894  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMED_7904  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_7920  [KO:K11410] [EC:1.3.8.5]
AMED_7921  [KO:K01968] [EC:6.4.1.4]
AMED_7922  [KO:K01969] [EC:6.4.1.4]
AMED_8108  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AMED_8367  acd; putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_8402  acd; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
AMED_9216  pdhA; pyruvate dehydrogenase E1 component subunit alpha [KO:K00166] [EC:1.2.4.4]
AMED_9217  pdhB; pyruvate dehydrogenase E1 component subunit beta [KO:K00167] [EC:1.2.4.4]
AMED_9218  pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [KO:K09699] [EC:2.3.1.168]
AMED_9234  atoB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
amd00020  Citrate cycle (TCA cycle)
amd00240  Pyrimidine metabolism
amd00290  Valine, leucine and isoleucine biosynthesis
amd00640  Propanoate metabolism
amd00900  Terpenoid backbone biosynthesis
amd01056  Biosynthesis of type II polyketide backbone
KO pathway
ko00280   

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