KEGG   PATHWAY: amq00360
Entry
amq00360                    Pathway                                
Name
Phenylalanine metabolism - Amycolatopsis methanolica
Class
Metabolism; Amino acid metabolism
Pathway map
amq00360  Phenylalanine metabolism
amq00360

Module
amq_M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:amq00360]
Other DBs
GO: 0006558
Organism
Amycolatopsis methanolica [GN:amq]
Gene
AMETH_0220  hcaD; FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00529] [EC:1.18.1.3]
AMETH_0287  hisC; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
AMETH_0503  paaG; enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
AMETH_0622  aspC; aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]
AMETH_0949  paaG; 2-ketocyclohexanecarboxyl-CoA hydrolase [KO:K15866] [EC:5.3.3.18]
AMETH_1183  [KO:K05714] [EC:3.7.1.14]
AMETH_1325  [KO:K00276] [EC:1.4.3.21]
AMETH_1390  fadB; 3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
AMETH_1808  aspC; class I and II aminotransferase [KO:K00812] [EC:2.6.1.1]
AMETH_1850  mhpB; 3-(2,3-dihydroxyphenyl)propionate dioxygenase [KO:K05713] [EC:1.13.11.16]
AMETH_1857  mhpC; putative hydrolase [KO:K05714] [EC:3.7.1.14]
AMETH_2022  [KO:K00146] [EC:1.2.1.39]
AMETH_2338  dadA2; glycine/D-amino acid oxidase, deaminating [KO:K00285] [EC:1.4.5.1]
AMETH_2409  mhpB; 3-carboxyethylcatechol 2,3-dioxygenase [KO:K05713] [EC:1.13.11.16]
AMETH_2562  [KO:K01426] [EC:3.5.1.4]
AMETH_2730  [KO:K00276] [EC:1.4.3.21]
AMETH_2975  mhpF; acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
AMETH_2976  mhpE; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
AMETH_3162  fadB; 3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
AMETH_3239  [KO:K00529] [EC:1.18.1.3]
AMETH_3599  katG; catalase/peroxidase [KO:K03782] [EC:1.11.1.21]
AMETH_3994  paaK; phenylacetate--CoA ligase [KO:K01912] [EC:6.2.1.30]
AMETH_4196  [KO:K05712] [EC:1.14.13.127]
AMETH_4261  paaH; 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
AMETH_4494  hcaC2; phenylpropionate dioxygenase ferredoxin subunit [KO:K05710]
AMETH_4495  hcaD; NAD(FAD)-dependent dehydrogenase [KO:K00529] [EC:1.18.1.3]
AMETH_4526  katG; catalase/hydroperoxidase HPI(I) [KO:K03782] [EC:1.11.1.21]
AMETH_4557  paaG; putative enoyl-CoA hydratase/isomerase [KO:K15866] [EC:5.3.3.18]
AMETH_4604  mhpB; 3-(2,3-dihydroxyphenyl)propionate dioxygenase [KO:K05713] [EC:1.13.11.16]
AMETH_4609  gatA; amidase [KO:K01426] [EC:3.5.1.4]
AMETH_5094  hisC; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
AMETH_5221  paaE; phenylacetate-CoA oxygenase/reductase, PaaK subunit [KO:K02613]
AMETH_5222  paaD; phenylacetate-CoA oxygenase, PaaJ subunit [KO:K02612]
AMETH_5223  paaC; phenylacetate-CoA oxygenase, PaaI subunit [KO:K02611] [EC:1.14.13.149]
AMETH_5224  paaB; phenylacetate-CoA oxygenase subunit PaaB [KO:K02610]
AMETH_5225  paaA; phenylacetic acid degradation protein PaaA [KO:K02609] [EC:1.14.13.149]
AMETH_5226  paaZ; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase [KO:K02618] [EC:3.3.2.12 1.2.1.91]
AMETH_5227  paaG; enoyl-CoA hydratase/isomerase [KO:K15866] [EC:5.3.3.18]
AMETH_5228  paaI; phenylacetic acid degradation protein PaaD [KO:K02614] [EC:3.1.2.-]
AMETH_5229  paaK; phenylacetate-CoA ligase [KO:K01912] [EC:6.2.1.30]
AMETH_5363  fprD; ferredoxin reductase [KO:K00529] [EC:1.18.1.3]
AMETH_5436  [KO:K02554] [EC:4.2.1.80]
AMETH_5454  hisC; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
AMETH_5522  paaG; enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
AMETH_5883  hpd3; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
AMETH_5897  amiE; amidase [KO:K01426] [EC:3.5.1.4]
AMETH_6013  [KO:K01593] [EC:4.1.1.28 4.1.1.105]
AMETH_6105  [KO:K00529] [EC:1.18.1.3]
AMETH_6190  paaG; 2-ketocyclohexanecarboxyl-CoA hydrolase [KO:K15866] [EC:5.3.3.18]
AMETH_6905  fadB2; 3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
C23049  Polyporic acid
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
amq00010  Glycolysis / Gluconeogenesis
amq00020  Citrate cycle (TCA cycle)
amq00350  Tyrosine metabolism
amq00362  Benzoate degradation
amq00400  Phenylalanine, tyrosine and tryptophan biosynthesis
amq00643  Styrene degradation
KO pathway
ko00360   

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