KEGG   PATHWAY: aroo01055
Entry
aroo01055                   Pathway                                
Name
Biosynthesis of vancomycin group antibiotics - Amycolatopsis roodepoortensis
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
aroo01055  Biosynthesis of vancomycin group antibiotics
aroo01055

Drug
D00212  Vancomycin (USP)
Organism
Amycolatopsis roodepoortensis [GN:aroo]
Gene
NQK81_06635  [KO:K01710] [EC:4.2.1.46]
NQK81_11520  [KO:K16431] [EC:1.14.19.-]
NQK81_15360  [KO:K16426]
NQK81_15365  [KO:K16427] [EC:1.13.11.80]
NQK81_15370  [KO:K16425]
NQK81_15375  [KO:K16424] [EC:2.3.1.246]
NQK81_15385  [KO:K16438] [EC:5.1.3.-]
NQK81_15390  [KO:K16436] [EC:2.6.1.- 2.6.1.106]
NQK81_15400  [KO:K16435] [EC:4.2.1.159]
NQK81_15405  [KO:K16422] [EC:1.1.3.46]
NQK81_15410  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K16421] [EC:1.13.11.46]
NQK81_15415  [KO:K16433]
NQK81_15420  [KO:K16432]
NQK81_15425  [KO:K16434]
NQK81_15430  [KO:K16423] [EC:2.6.1.103]
NQK81_15450  [KO:K16444] [EC:2.4.1.310]
NQK81_15460  [KO:K16444] [EC:2.4.1.310]
NQK81_15465  [KO:K16444] [EC:2.4.1.310]
NQK81_15470  [KO:K16444] [EC:2.4.1.310]
NQK81_15475  [KO:K16447]
NQK81_15480  [KO:K16446]
NQK81_15485  [KO:K16445]
NQK81_15490  [KO:K16445]
NQK81_15500  [KO:K16430]
NQK81_15505  [KO:K16429]
NQK81_15515  [KO:K16428]
NQK81_17925  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
NQK81_30300  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K16421] [EC:1.13.11.46]
NQK81_32135  [KO:K16438] [EC:5.1.3.-]
NQK81_33260  [KO:K16444] [EC:2.4.1.310]
Compound
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00842  dTDP-glucose
C01179  3-(4-Hydroxyphenyl)pyruvate
C03198  (S)-4-Hydroxymandelate
C03590  4-Hydroxyphenylglyoxylate
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C06689  Vancomycin
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12014  Chloroeremomycin
C12026  3,5-Dihydroxy-phenylglycine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12319  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
C12320  dTDP-L-4-oxovancosamine
C12321  dTDP-L-epivancosamine
C12322  dTDP-L-vancosamine
C12323  L-4-Hydroxyphenylglycine
C12324  3,5-Dihydroxyphenylacetyl-CoA
C12325  3,5-Dihydroxyphenylglyoxylate
Reference
PMID:24884615
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
Reference
PMID:12596194
  Authors
Hubbard BK, Walsh CT.
  Title
Vancomycin assembly: nature's way.
  Journal
Angew Chem Int Ed Engl 42:730-65 (2003)
DOI:10.1002/anie.200390202
Reference
PMID:11035791
  Authors
Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD.
  Title
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 97:11942-7 (2000)
DOI:10.1073/pnas.210395097
Reference
PMID:9545426
  Authors
van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.
  Title
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
  Journal
Chem Biol 5:155-62 (1998)
DOI:10.1016/S1074-5521(98)90060-6
Related
pathway
aroo00400  Phenylalanine, tyrosine and tryptophan biosynthesis
aroo00520  Amino sugar and nucleotide sugar metabolism
aroo00620  Pyruvate metabolism
KO pathway
ko01055   

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