KEGG   PATHWAY: bsu00550
Entry
bsu00550                    Pathway                                
Name
Peptidoglycan biosynthesis - Bacillus subtilis subsp. subtilis 168
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
bsu00550  Peptidoglycan biosynthesis
bsu00550

Organism
Bacillus subtilis subsp. subtilis 168 [GN:bsu]
Gene
BSU37100  murAB; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 [KO:K00790] [EC:2.5.1.7]
BSU36760  murAA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 [KO:K00790] [EC:2.5.1.7]
BSU15230  murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
BSU29790  murC; UDP-N-acetylmuramate--L-alanine ligase [KO:K01924] [EC:6.3.2.8]
BSU15200  murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [KO:K01925] [EC:6.3.2.9]
BSU15180  murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [KO:K01928] [EC:6.3.2.13]
BSU04560  ddl; D-alanine--D-alanine ligase [KO:K01921] [EC:6.3.2.4]
BSU04570  murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [KO:K01929] [EC:6.3.2.10]
BSU25310  dgkA; undecaprenol kinase [KO:K00887] [EC:2.7.1.66]
BSU16530  uppS; undecaprenyl pyrophosphate synthase [KO:K00806] [EC:2.5.1.31]
BSU31150  yubB; undecaprenyl-diphosphatase [KO:K06153] [EC:3.6.1.27]
BSU36530  bcrC; undecaprenyl-diphosphatase BcrC [KO:K19302] [EC:3.6.1.27]
BSU15190  mraY; phospho-n-acetylmuramoyl-pentapeptide-transferase [KO:K01000] [EC:2.7.8.13]
BSU15220  murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563] [EC:2.4.1.227]
BSU22320  ponA; penicillin-binding protein 1A/1B [KO:K05366] [EC:2.4.1.129 3.4.16.4]
BSU10110  pbpF; penicillin-binding protein 1F [KO:K12555] [EC:2.4.1.129 3.4.16.4]
BSU31490  pbpD; penicillin-binding protein 4 [KO:K18770] [EC:2.4.1.129 3.4.16.4]
BSU37510  pbpG; penicillin-binding protein 2D [KO:K21464] [EC:2.4.1.129 3.4.16.4]
BSU15160  pbpB; penicillin-binding protein 2B [KO:K08724]
BSU15170  spoVD; stage V sporulation protein D [KO:K08384]
BSU25000  pbpA; hypothetical protein [KO:K21465]
BSU13980  pbpH; penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall [KO:K21466]
BSU23480  dacF; D-alanyl-D-alanine carboxypeptidase DacF [KO:K07258] [EC:3.4.16.4]
BSU00100  dacA; D-alanyl-D-alanine carboxypeptidase DacA [KO:K07258] [EC:3.4.16.4]
BSU23190  dacB; D-alanyl-D-alanine carboxypeptidase DacB [KO:K07258] [EC:3.4.16.4]
BSU18350  dacC; D-alanyl-D-alanine carboxypeptidase DacC [KO:K07259] [EC:3.4.16.4 3.4.21.-]
BSU01670  ybbE; hypothetical protein [KO:K21469] [EC:3.4.16.4]
BSU19620  yodJ; carboxypeptidase YodJ [KO:K07260] [EC:3.4.17.14]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00133  D-Alanine
C00448  trans,trans-Farnesyl diphosphate
C00692  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C00993  D-Alanyl-D-alanine
C01050  UDP-N-acetylmuramate
C01212  UDP-N-acetylmuramoyl-L-alanine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702  UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851  MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896  Crosslinked peptidoglycan
C05897  Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556  di-trans,poly-cis-Undecaprenyl phosphate
C17558  di-trans,poly-cis-Undecaprenol
C22053  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference
  Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
  Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
  Journal
FEMS Microbiol Rev 32:208-33 (2008)
DOI:10.1111/j.1574-6976.2007.00089.x
Reference
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
  Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
  Title
Cytoplasmic steps of peptidoglycan biosynthesis.
  Journal
FEMS Microbiol Rev 32:168-207 (2008)
DOI:10.1111/j.1574-6976.2008.00104.x
Reference
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Reference
  Authors
van Heijenoort  J
  Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
  Journal
Glycobiology 11:25R-36R (2001)
DOI:10.1093/glycob/11.3.25R
Related
pathway
bsu00470  D-Amino acid metabolism
bsu00520  Amino sugar and nucleotide sugar metabolism
bsu00900  Terpenoid backbone biosynthesis
KO pathway
ko00550   
LinkDB

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