KEGG   PATHWAY: bxb00061
Entry
bxb00061                    Pathway                                
Name
Fatty acid biosynthesis - Paraburkholderia xenovorans LB400
Class
Metabolism; Lipid metabolism
Pathway map
bxb00061  Fatty acid biosynthesis
bxb00061

Module
bxb_M00082  Fatty acid biosynthesis, initiation [PATH:bxb00061]
bxb_M00083  Fatty acid biosynthesis, elongation [PATH:bxb00061]
bxb_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:bxb00061]
Other DBs
GO: 0006633
Organism
Paraburkholderia xenovorans LB400 [GN:bxb]
Gene
DR64_3786  accA; acetyl-CoA carboxylase, carboxyl transferase, alpha subunit [KO:K01962] [EC:6.4.1.2 2.1.3.15]
DR64_2707  accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein [KO:K02160]
DR64_2706  accC; acetyl-CoA carboxylase, biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
DR64_5208  accD; acetyl-CoA carboxylase, carboxyl transferase, beta subunit [KO:K01963] [EC:6.4.1.2 2.1.3.15]
DR64_3236  fabD; malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
DR64_3235  fabH; 3-oxoacyl-(Acyl-carrier-protein) synthase III [KO:K00648] [EC:2.3.1.180]
DR64_2271  3-Oxoacyl-[acyl-carrier-(ACP)] synthase III family protein [KO:K00648] [EC:2.3.1.180]
DR64_2273  fabH; 3-oxoacyl-(Acyl-carrier-protein) synthase III [KO:K00648] [EC:2.3.1.180]
DR64_8020  3-Oxoacyl-[acyl-carrier-(ACP)] synthase III family protein [KO:K00648] [EC:2.3.1.180]
DR64_3103  hypothetical protein [KO:K00647] [EC:2.3.1.41]
DR64_3099  hypothetical protein [KO:K00647] [EC:2.3.1.41]
DR64_3239  fabF; beta-ketoacyl-acyl-carrier-protein synthase II [KO:K09458] [EC:2.3.1.179]
DR64_3102  hypothetical protein [KO:K09458] [EC:2.3.1.179]
DR64_3237  fabG; 3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
DR64_1774  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_5606  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_4254  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_4269  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_4486  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_3101  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_1102  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_1229  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_376  3-beta hydroxysteroid dehydrogenase/isomerase family protein [KO:K00059] [EC:1.1.1.100]
DR64_959  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_4998  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_5028  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_5061  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_458  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_689  polysaccharide biosynthesis family protein [KO:K00059] [EC:1.1.1.100]
DR64_7830  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_7857  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_1307  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_7550  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_7855  short chain dehydrogenase family protein [KO:K00059] [EC:1.1.1.100]
DR64_3858  fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
DR64_5678  fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
DR64_3795  short chain dehydrogenase family protein [KO:K00208] [EC:1.3.1.9 1.3.1.10]
DR64_5695  short chain dehydrogenase family protein [KO:K00208] [EC:1.3.1.9 1.3.1.10]
DR64_8374  short chain dehydrogenase family protein [KO:K00208] [EC:1.3.1.9 1.3.1.10]
DR64_4351  NAD(P)H binding domain of trans-2-enoyl-CoA reductase family protein [KO:K00209] [EC:1.3.1.9 1.3.1.44]
DR64_2650  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
DR64_461  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
DR64_7203  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
DR64_4865  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
DR64_4844  AMP-binding enzyme family protein [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
bxb00020  Citrate cycle (TCA cycle)
bxb00071  Fatty acid degradation
bxb00410  beta-Alanine metabolism
bxb00561  Glycerolipid metabolism
bxb00564  Glycerophospholipid metabolism
bxb00620  Pyruvate metabolism
bxb00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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