KEGG   PATHWAY: bxb00360
Entry
bxb00360                    Pathway                                
Name
Phenylalanine metabolism - Paraburkholderia xenovorans LB400
Class
Metabolism; Amino acid metabolism
Pathway map
bxb00360  Phenylalanine metabolism
bxb00360

Module
bxb_M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:bxb00360]
Other DBs
GO: 0006558
Organism
Paraburkholderia xenovorans LB400 [GN:bxb]
Gene
DR64_2191  phhA; phenylalanine-4-hydroxylase [KO:K00500] [EC:1.14.16.1]
DR64_6842  FAD binding domain protein [KO:K00274] [EC:1.4.3.4]
DR64_5458  aldehyde dehydrogenase family protein [KO:K00146] [EC:1.2.1.39]
DR64_2637  paaF; phenylacetate-CoA ligase [KO:K01912] [EC:6.2.1.30]
DR64_7530  AMP-binding enzyme family protein [KO:K01912] [EC:6.2.1.30]
DR64_2638  paaD; phenylacetic acid degradation protein PaaD [KO:K02614] [EC:3.1.2.-]
DR64_2457  phenylacetic acid catabolic family protein [KO:K02609] [EC:1.14.13.149]
DR64_2456  phenylacetic acid degradation B [KO:K02610]
DR64_2455  phenylacetic acid catabolic family protein [KO:K02611] [EC:1.14.13.149]
DR64_2454  paaJ; phenylacetate-CoA oxygenase, PaaJ subunit [KO:K02612]
DR64_2453  2Fe-2S iron-sulfur cluster binding domain protein [KO:K02613]
DR64_2639  paaB; phenylacetate degradation putative enoyl-CoA hydratase PaaB [KO:K15866] [EC:5.3.3.18]
DR64_8104  enoyl-CoA hydratase/isomerase family protein [KO:K15866] [EC:5.3.3.18]
DR64_8155  enoyl-CoA hydratase/isomerase family protein [KO:K15866] [EC:5.3.3.18]
DR64_8164  enoyl-CoA hydratase/isomerase family protein [KO:K15866] [EC:5.3.3.18]
DR64_2642  enoyl-CoA hydratase/isomerase family protein [KO:K01692] [EC:4.2.1.17]
DR64_885  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_5275  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_5715  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_8767  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_8768  hypothetical protein [KO:K00074] [EC:1.1.1.157]
DR64_8103  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_8156  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_7421  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_7562  putative 3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
DR64_7850  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein [KO:K00074] [EC:1.1.1.157]
DR64_3139  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
DR64_2569  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
DR64_1813  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
DR64_6537  tyrB; tyrosine aminotransferase [KO:K00832] [EC:2.6.1.57]
DR64_844  aminotransferase class I and II family protein [KO:K00832] [EC:2.6.1.57]
DR64_664  acetyltransferase domain protein [KO:K03825] [EC:2.3.1.53 2.3.1.-]
DR64_665  acetyltransferase family protein [KO:K03825] [EC:2.3.1.53 2.3.1.-]
DR64_5106  glyoxalase/Bleomycin resistance/Dioxygenase superfamily protein [KO:K00457] [EC:1.13.11.27]
DR64_2448  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
DR64_6655  ketopantoate reductase PanE/ApbA family protein [KO:K00285] [EC:1.4.5.1]
DR64_2539  FAD binding domain protein [KO:K00285] [EC:1.4.5.1]
DR64_3162  ketopantoate reductase PanE/ApbA family protein [KO:K00285] [EC:1.4.5.1]
DR64_8038  ketopantoate reductase PanE/ApbA family protein [KO:K00285] [EC:1.4.5.1]
DR64_1894  aminotransferase class IV family protein [KO:K00824] [EC:2.6.1.21]
DR64_2939  katG; catalase/peroxidase HPI [KO:K03782] [EC:1.11.1.21]
DR64_2006  amidase family protein [KO:K01426] [EC:3.5.1.4]
DR64_4255  amidase family protein [KO:K01426] [EC:3.5.1.4]
DR64_6379  amidase family protein [KO:K01426] [EC:3.5.1.4]
DR64_8562  amidase family protein [KO:K01426] [EC:3.5.1.4]
DR64_5519  rieske [2Fe-2S] domain protein [KO:K05710]
DR64_1288  FAD binding domain protein [KO:K00529] [EC:1.18.1.3]
DR64_7867  thcD; rhodocoxin reductase [KO:K00529] [EC:1.18.1.3]
DR64_7499  FAD dependent oxidoreductase family protein [KO:K00529] [EC:1.18.1.3]
DR64_5531  NAD(P)-binding family protein [KO:K00529] [EC:1.18.1.3]
DR64_6541  FAD binding domain protein [KO:K05712] [EC:1.14.13.127]
DR64_4661  mhpA; 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase [KO:K05712] [EC:1.14.13.127]
DR64_5764  FAD binding domain protein [KO:K05712] [EC:1.14.13.127]
DR64_410  FAD binding domain protein [KO:K05712] [EC:1.14.13.127]
DR64_7461  FAD binding domain protein [KO:K05712] [EC:1.14.13.127]
DR64_4660  mhpB; 2,3-dihydroxyphenylpropionate/2, 3-dihydroxicinnamic acid 1,2-dioxygenase [KO:K05713] [EC:1.13.11.16]
DR64_4655  mhpC; 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase [KO:K05714] [EC:3.7.1.14]
DR64_4659  mhpD; 2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
DR64_3308  mhpD; 2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
DR64_1247  amnF; 2-oxopent-4-enoate hydratase [KO:K02554] [EC:4.2.1.80]
DR64_4161  putative hydratase/decarboxylase [KO:K02554] [EC:4.2.1.80]
DR64_4657  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
DR64_1245  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
DR64_3311  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
DR64_4658  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
DR64_1246  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
DR64_3310  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
bxb00010  Glycolysis / Gluconeogenesis
bxb00020  Citrate cycle (TCA cycle)
bxb00350  Tyrosine metabolism
bxb00362  Benzoate degradation
bxb00400  Phenylalanine, tyrosine and tryptophan biosynthesis
bxb00643  Styrene degradation
KO pathway
ko00360   
LinkDB

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