KEGG   PATHWAY: bxb00350
Entry
bxb00350                    Pathway                                
Name
Tyrosine metabolism - Paraburkholderia xenovorans LB400
Class
Metabolism; Amino acid metabolism
Pathway map
bxb00350  Tyrosine metabolism
bxb00350

Module
bxb_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:bxb00350]
bxb_M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:bxb00350]
Other DBs
GO: 0006570
Organism
Paraburkholderia xenovorans LB400 [GN:bxb]
Gene
DR64_3139  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
DR64_2569  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
DR64_1813  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
DR64_6537  tyrB; tyrosine aminotransferase [KO:K00832] [EC:2.6.1.57]
DR64_844  aminotransferase class I and II family protein [KO:K00832] [EC:2.6.1.57]
DR64_5106  glyoxalase/Bleomycin resistance/Dioxygenase superfamily protein [KO:K00457] [EC:1.13.11.27]
DR64_2448  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
DR64_1576  hmgA; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
DR64_408  hmgA; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
DR64_7427  hmgA; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
DR64_7457  hmgA; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
DR64_319  maiA; maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
DR64_406  maiA; maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
DR64_1818  maiA; maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
DR64_4855  fahA; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
DR64_1575  fahA; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
DR64_407  fahA; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
DR64_7456  fahA; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
DR64_1911  fumarylacetoacetate (FAA) hydrolase family protein [KO:K16171] [EC:3.7.1.2]
DR64_7545  fumarylacetoacetate (FAA) hydrolase family protein [KO:K16171] [EC:3.7.1.2]
DR64_6842  FAD binding domain protein [KO:K00274] [EC:1.4.3.4]
DR64_5458  aldehyde dehydrogenase family protein [KO:K00146] [EC:1.2.1.39]
DR64_2881  S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
DR64_4005  zinc-binding alcohol dehydrogenase family protein [KO:K13953] [EC:1.1.1.1]
DR64_4034  zinc-binding dehydrogenase family protein [KO:K13953] [EC:1.1.1.1]
DR64_7920  zinc-binding dehydrogenase family protein [KO:K13953] [EC:1.1.1.1]
DR64_4641  hpaC; 4-hydroxyphenylacetate 3-monooxygenase, reductase component [KO:K00484] [EC:1.5.1.36]
DR64_7333  hpaD; 3,4-dihydroxyphenylacetate 2,3-dioxygenase [KO:K00455] [EC:1.13.11.15]
DR64_7332  hpaE; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase [KO:K00151] [EC:1.2.1.60]
DR64_7334  5-carboxymethyl-2-hydroxymuconate isomerase family protein [KO:K01826] [EC:5.3.3.10]
DR64_7330  fumarylacetoacetate (FAA) hydrolase family protein [KO:K05921] [EC:4.1.1.68 5.3.3.-]
DR64_7331  hpaG; 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase [KO:K05921] [EC:4.1.1.68 5.3.3.-]
DR64_7335  hpaH; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase [KO:K02509] [EC:4.2.1.-]
DR64_7336  hpaI; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [KO:K02510] [EC:4.1.2.52]
DR64_6155  gabD; succinate-semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_4695  aldehyde dehydrogenase family protein [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_4215  aldehyde dehydrogenase family protein [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_6792  aldehyde dehydrogenase family protein [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_7276  gabD; succinate-semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_8133  gabD; succinate-semialdehyde dehydrogenase [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_7722  aldehyde dehydrogenase family protein [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_7779  succinate-semialdehyde dehydrogenase family protein [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_7924  aldehyde dehydrogenase family protein [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
DR64_317  gtdA; gentisate 1,2-dioxygenase [KO:K00450] [EC:1.13.11.4]
DR64_1819  fumarylacetoacetate (FAA) hydrolase family protein [KO:K16165] [EC:3.7.1.20]
DR64_318  fumarylacetoacetate (FAA) hydrolase family protein [KO:K16165] [EC:3.7.1.20]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
bxb00020  Citrate cycle (TCA cycle)
bxb00360  Phenylalanine metabolism
bxb00400  Phenylalanine, tyrosine and tryptophan biosynthesis
bxb00620  Pyruvate metabolism
bxb00621  Dioxin degradation
bxb00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

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