KEGG   PATHWAY: cbr04980
Entry
cbr04980                    Pathway                                
Name
Cobalamin transport and metabolism - Caenorhabditis briggsae (nematode)
Class
Organismal Systems; Digestive system
Pathway map
cbr04980  Cobalamin transport and metabolism
cbr04980

Organism
Caenorhabditis briggsae (nematode) [GN:cbr]
Gene
CBG_00882  Cbr-mtrr-1; Protein CBR-MTRR-1 [KO:K00597] [EC:1.16.1.8]
CBG_03603  Cbr-mmcm-1; Protein CBR-MMCM-1 [KO:K01847] [EC:5.4.99.2]
CBG_04568  Cbr-pmp-3; Protein CBR-PMP-3 [KO:K05678] [EC:7.6.2.8]
CBG_13064  Cbr-mmaa-1; Protein CBR-MMAA-1 [KO:K07588] [EC:3.6.5.-]
CBG_15313  [KO:K26006]
CBG_18191  Cbr-mmab-1; Protein CBR-MMAB-1 [KO:K00798] [EC:2.5.1.17]
CBG_18988  Cbr-pmp-5; Protein CBR-PMP-5 [KO:K05678] [EC:7.6.2.8]
CBG_20636  Cbr-metr-1; Protein CBR-METR-1 [KO:K00548] [EC:2.1.1.13]
CBG_25150  Cbr-prdx-2; Protein CBR-PRDX-2 [KO:K13279] [EC:1.11.1.24]
CBG_28142  [KO:K14618] [EC:1.16.1.6 2.5.1.151]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews (1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
cbr00270  Cysteine and methionine metabolism
cbr00280  Valine, leucine and isoleucine degradation
cbr00670  One carbon pool by folate
cbr04144  Endocytosis
cbr04977  Vitamin digestion and absorption
KO pathway
ko04980   

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