KEGG   PATHWAY: ko04980
Entry
ko04980                     Pathway                                
Name
Cobalamin transport and metabolism
Class
Organismal Systems; Digestive system
Pathway map
ko04980  Cobalamin transport and metabolism
ko04980

Orthology
K00548  metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
K00597  MTRR; methionine synthase reductase [EC:1.16.1.8]
K00798  MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]
K01847  MUT; methylmalonyl-CoA mutase [EC:5.4.99.2]
K05678  ABCD4, PXMP1L; ATP-binding cassette, subfamily D (ALD), member 4 [EC:7.6.2.8]
K06734  CD320; CD320 antigen
K07588  MMAA, argK; GTPase [EC:3.6.5.-]
K13279  PRDX1; peroxiredoxin 1 [EC:1.11.1.24]
K14615  CBLIF, GIF, IF; gastric intrinsic factor
K14617  LMBRD1; LMBR1 domain-containing protein 1
K14618  MMACHC; cyanocobalamin reductase (cyanide-eliminating) / alkylcobalamin dealkylase [EC:1.16.1.6 2.5.1.151]
K14619  TCN2; transcobalamin-2
K14966  HCFC1; host cell factor 1
K20828  ZNF143_76, STAF; zinc finger protein 143/76
K23211  THAP11; THAP domain-containing protein 11
K25741  TCN1; transcobalamin-1
K26006  MMADHC; cobalamin trafficking protein CblD
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews (1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
ko00270  Cysteine and methionine metabolism
ko00280  Valine, leucine and isoleucine degradation
ko00670  One carbon pool by folate
ko04144  Endocytosis
ko04977  Vitamin digestion and absorption

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