KEGG   PATHWAY: cmk00533
Entry
cmk00533                    Pathway                                
Name
Glycosaminoglycan biosynthesis - keratan sulfate - Callorhinchus milii (elephant shark)
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
cmk00533  Glycosaminoglycan biosynthesis - keratan sulfate
cmk00533

Other DBs
GO: 0018146
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103175217  alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
103177647  b4galt1l; beta-1,4-galactosyltransferase 1 [KO:K07966] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
103181973  beta-1,4-galactosyltransferase 2 isoform X1 [KO:K07967] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
103182791  b4galt2; beta-1,4-galactosyltransferase 2 isoform X1 [KO:K07967] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
103184325  beta-1,4-galactosyltransferase 3-like isoform X1 [KO:K07968] [EC:2.4.1.90 2.4.1.38 2.4.1.-]
103173573  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2-like [KO:K00741] [EC:2.4.1.149]
103177950  b3gnt2b; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 [KO:K00741] [EC:2.4.1.149]
103175980  chst6; carbohydrate sulfotransferase 6 [KO:K09671] [EC:2.8.2.-]
103185094  b4galt4; beta-1,4-galactosyltransferase 4 [KO:K07969] [EC:2.4.1.90 2.4.1.275 2.4.1.-]
103181372  b3gnt7l; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, like [KO:K09664] [EC:2.4.1.-]
103184417  b3gnt7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 [KO:K09664] [EC:2.4.1.-]
103175104  chst1; carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
103179901  si:ch73-62b13.1; carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
103174609  st3gal3a; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase [KO:K00781] [EC:2.4.3.6]
103177929  chst2b; carbohydrate sulfotransferase 2 [KO:K04745] [EC:2.8.2.-]
103189009  CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1 [KO:K00780] [EC:2.4.3.2 2.4.3.4]
103186659  st3gal2; CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.3.2 2.4.3.4]
Reference
PMID:11030741
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
DOI:10.1093/glycob/10.10.951
Reference
PMID:14706853
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
DOI:10.1016/S0014-5793(03)01440-6
Reference
PMID:12511560
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)
DOI:10.1074/jbc.M211480200
Related
pathway
cmk00510  N-Glycan biosynthesis
cmk00512  Mucin type O-glycan biosynthesis
KO pathway
ko00533   
LinkDB

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