KEGG   PATHWAY: cnc00350
Entry
cnc00350                    Pathway                                
Name
Tyrosine metabolism - Cupriavidus necator N-1
Class
Metabolism; Amino acid metabolism
Pathway map
cnc00350  Tyrosine metabolism
cnc00350

Module
cnc_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:cnc00350]
Other DBs
GO: 0006570
Organism
Cupriavidus necator N-1 [GN:cnc]
Gene
CNE_BB1p10300  aatB; aspartate aminotransferase AatB [KO:K00812] [EC:2.6.1.1]
CNE_BB1p00650  aatA1; aspartate aminotransferase AatA [KO:K00812] [EC:2.6.1.1]
CNE_BB1p09670  aatA2; aspartate aminotransferase AatA [KO:K00812] [EC:2.6.1.1]
CNE_1c08050  hisC1; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
CNE_1c33560  hisC2; histidinol-phosphate aminotransferase [KO:K00817] [EC:2.6.1.9]
CNE_1c10930  tyrB; tyrosine aminotransferase TyrB [KO:K00832] [EC:2.6.1.57]
CNE_2c10400  tyrB; aromatic-amino-acid aminotransferase TyrB [KO:K00832] [EC:2.6.1.57]
CNE_2c10420  hpd; 4-hydroxyphenylpyruvate dioxygenase Hpd [KO:K00457] [EC:1.13.11.27]
CNE_2c18250  4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
CNE_2c16640  hmgA; homogentisate 1,2-dioxygenase HmgA [KO:K00451] [EC:1.13.11.5]
CNE_BB2p00950  hypothetical protein [KO:K00451] [EC:1.13.11.5]
CNE_2c08330  maiA; maleylacetoacetate isomerase MaiA [KO:K01800] [EC:5.2.1.2]
CNE_1c03790  maiA1; maleylacetoacetate isomerase MaiA [KO:K01800] [EC:5.2.1.2]
CNE_2c16630  fahA; fumarylacetoacetase hydrolase FahA [KO:K01555] [EC:3.7.1.2]
CNE_BB1p00850  fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
CNE_1c01340  mhpD1; 2-oxopent-4-enoate hydratase MhpD [KO:K16171] [EC:3.7.1.2]
CNE_1c00190  flhA; S-(hydroxymethyl)glutathione dehydrogenase FlhA [KO:K00121] [EC:1.1.1.284 1.1.1.1]
CNE_2c11700  flhA2; S-(hydroxymethyl)glutathione dehydrogenase FlhA [KO:K00121] [EC:1.1.1.284 1.1.1.1]
CNE_BB1p12270  flhA; S-(hydroxymethyl)glutathione dehydrogenase FlhA [KO:K00121] [EC:1.1.1.284 1.1.1.1]
CNE_2c13630  adhA; alcohol dehydrogenase AdhA [KO:K13953] [EC:1.1.1.1]
CNE_2c13570  mdh2; NAD-dependent methanol dehydrogenase Mdh [KO:K13954] [EC:1.1.1.1]
CNE_1c17820  zinc-containing alcohol dehydrogenase superfamily [KO:K00001] [EC:1.1.1.1]
CNE_2c04450  hpaH; 4-hydroxyphenylacetate 3-monooxygenase oxygenase component HpaH [KO:K00483] [EC:1.14.14.9]
CNE_BB2p02560  hypothetical protein [KO:K01826] [EC:5.3.3.10]
CNE_2c12210  5-carboxymethyl-2-hydroxymuconate isomerase [KO:K01826] [EC:5.3.3.10]
CNE_BB1p12710  hpcG; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase HpcG [KO:K02509] [EC:4.2.1.-]
CNE_2c11440  hpaI; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase HpaI [KO:K02510] [EC:4.1.2.52]
CNE_BB1p12700  hpcH; 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase HpcH [KO:K02510] [EC:4.1.2.52]
CNE_2c15390  gabD3; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_BB2p03440  gabD; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_2c09410  gabD1; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_1c17420  gabD; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_2c11430  gabD2; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_BB1p10210  gabD2; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_2c20080  gabD4; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_BB1p00670  gabD1; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_BB1p01510  NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_BB1p12560  gabD3; NADP+ dependend succinate-semialdehyde dehydrogenase GabD [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
CNE_BB1p08740  xylB1; aryl-alcohol dehydrogenase XylB [KO:K00055] [EC:1.1.1.90]
CNE_BB1p09200  xylB2; aryl-alcohol dehydrogenase XylB [KO:K00055] [EC:1.1.1.90]
CNE_BB2p02190  nagI; gentisate 1,2-dioxygenase oxidoreductase protein NagI [KO:K00450] [EC:1.13.11.4]
CNE_2c08310  gentisate 1,2-dioxygenase [KO:K00450] [EC:1.13.11.4]
CNE_BB2p00870  gentisate 1,2-dioxygenase [KO:K00450] [EC:1.13.11.4]
CNE_2c20800  gentisate 1,2-dioxygenase [KO:K00450] [EC:1.13.11.4]
CNE_1c03780  fumarylacetoacetat hydroxylase [KO:K16165] [EC:3.7.1.20]
CNE_2c08320  fumarylpyruvate hydrolase [KO:K16165] [EC:3.7.1.20]
CNE_BB2p00710  fumarylacetoacetate hydrolase [KO:K16165] [EC:3.7.1.20]
CNE_2c09100  malate/L-lactate dehydrogenase [KO:K13574] [EC:1.1.1.237 1.1.1.-]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
cnc00020  Citrate cycle (TCA cycle)
cnc00360  Phenylalanine metabolism
cnc00400  Phenylalanine, tyrosine and tryptophan biosynthesis
cnc00620  Pyruvate metabolism
cnc00621  Dioxin degradation
cnc00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

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