KEGG   PATHWAY: cpor00260
Entry
cpor00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cloacibacillus porcorum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cpor00260  Glycine, serine and threonine metabolism
cpor00260

Module
cpor_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cpor00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cloacibacillus porcorum [GN:cpor]
Gene
BED41_07035  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BED41_07040  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BED41_11900  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BED41_00710  hypothetical protein [KO:K00003] [EC:1.1.1.3]
BED41_00780  hypothetical protein [KO:K00003] [EC:1.1.1.3]
BED41_07030  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BED41_07025  threonine synthase [KO:K01733] [EC:4.2.3.1]
BED41_09160  threonine synthase [KO:K01733] [EC:4.2.3.1]
BED41_15730  threonine aldolase [KO:K01620] [EC:4.1.2.48]
BED41_02675  threonine aldolase [KO:K01620] [EC:4.1.2.48]
BED41_14265  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BED41_12455  hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
BED41_04765  hypothetical protein [KO:K11529] [EC:2.7.1.165]
BED41_13715  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BED41_07800  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BED41_03610  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BED41_07805  phosphoglycerate mutase [KO:K22305] [EC:3.1.3.3]
BED41_04600  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BED41_04605  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BED41_10765  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
BED41_10760  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
BED41_05315  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BED41_13005  L-serine dehydratase, iron-sulfur-dependent subunit alpha [KO:K01752] [EC:4.3.1.17]
BED41_13010  L-serine dehydratase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
BED41_09580  hypothetical protein [KO:K01752] [EC:4.3.1.17]
BED41_01675  serine dehydratase [KO:K01752] [EC:4.3.1.17]
BED41_03945  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BED41_00980  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BED41_09125  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BED41_07155  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BED41_09130  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cpor00010  Glycolysis / Gluconeogenesis
cpor00020  Citrate cycle (TCA cycle)
cpor00230  Purine metabolism
cpor00250  Alanine, aspartate and glutamate metabolism
cpor00270  Cysteine and methionine metabolism
cpor00290  Valine, leucine and isoleucine biosynthesis
cpor00300  Lysine biosynthesis
cpor00330  Arginine and proline metabolism
cpor00460  Cyanoamino acid metabolism
cpor00470  D-Amino acid metabolism
cpor00564  Glycerophospholipid metabolism
cpor00620  Pyruvate metabolism
cpor00630  Glyoxylate and dicarboxylate metabolism
cpor00640  Propanoate metabolism
cpor00680  Methane metabolism
cpor00860  Porphyrin metabolism
cpor00920  Sulfur metabolism
KO pathway
ko00260   
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