KEGG   PATHWAY: csyr04721
Entry
csyr04721                   Pathway                                
Name
Synaptic vesicle cycle - Carlito syrichta (Philippine tarsier)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
csyr04721  Synaptic vesicle cycle
csyr04721

Other DBs
GO: 0016079 0048488
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249351  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
103249721  NAPA; alpha-soluble NSF attachment protein isoform X1 [KO:K15296]
103250233  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X3 [KO:K02154]
103250585  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
103251303  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
103251529  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
103251697  CPLX2; complexin-2 [KO:K15294]
103251850  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
103252226  STX1A; syntaxin-1A [KO:K04560]
103252465  [KO:K07882]
103254908  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
103255146  [KO:K02155]
103255440  SLC1A7; excitatory amino acid transporter 5 isoform X1 [KO:K05618]
103255497  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X2 [KO:K15291]
103255516  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103255975  [KO:K23484]
103256027  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
103256625  [KO:K01528] [EC:3.6.5.5]
103257496  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
103257511  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
103257766  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103258089  AP2A1; AP-2 complex subunit alpha-1 [KO:K11824]
103258142  SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
103258166  [KO:K02155]
103258846  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
103259075  [KO:K02146]
103259170  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
103259547  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
103259682  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
103259862  CPLX4; complexin-4 [KO:K15295]
103260759  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X2 [KO:K03661]
103260761  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X4 [KO:K05038]
103261161  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
103261579  UNC13C; protein unc-13 homolog C isoform X3 [KO:K15293]
103261755  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
103261977  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
103262033  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
103262043  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
103262570  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
103262572  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
103263366  SLC6A7; sodium-dependent proline transporter [KO:K05040]
103263468  VAMP2; vesicle-associated membrane protein 2 isoform X1 [KO:K13504]
103263556  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
103263925  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
103264384  STX1B; syntaxin-1B [KO:K08486]
103264405  STXBP1; syntaxin-binding protein 1 [KO:K15292]
103264706  ATP6V1G3; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 3 [KO:K02152]
103265266  CLTA; clathrin light chain A isoform X1 [KO:K04644]
103265403  SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
103265431  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
103265477  UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293]
103265947  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
103266304  AP2A2; AP-2 complex subunit alpha-2 isoform X2 [KO:K11824]
103266400  CPLX1; complexin-1 [KO:K15294]
103266428  AP2S1; AP-2 complex subunit sigma [KO:K11827]
103266566  CPLX3; complexin-3 [KO:K15295]
103267083  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
103267631  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
103267979  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
103268380  [KO:K02153]
103268402  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
103269045  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
103269435  CLTCL1; clathrin heavy chain 2 isoform X2 [KO:K04646]
103270146  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
103270920  [KO:K02155]
103271220  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
103271885  STX2; syntaxin-2 [KO:K08486]
103272099  SLC1A2; excitatory amino acid transporter 2 [KO:K05613]
103272149  SLC1A6; excitatory amino acid transporter 4 isoform X1 [KO:K05617]
103272319  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
103273209  DNM3; dynamin-3 isoform X2 [KO:K01528] [EC:3.6.5.5]
103273270  AP2M1; AP-2 complex subunit mu isoform X2 [KO:K11826]
103273290  STX3; syntaxin-3 isoform X2 [KO:K08486]
103273412  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
103274224  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
103274462  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
103275988  CLTB; clathrin light chain B [KO:K04645]
103276577  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
103276578  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
103276834  AP2B1; AP-2 complex subunit beta [KO:K11825]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
csyr04144  Endocytosis
csyr04724  Glutamatergic synapse
csyr04725  Cholinergic synapse
csyr04726  Serotonergic synapse
csyr04727  GABAergic synapse
csyr04728  Dopaminergic synapse
KO pathway
ko04721   

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