KEGG   PATHWAY: cuh00290
Entry
cuh00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Cupriavidus necator NH9
Class
Metabolism; Amino acid metabolism
Pathway map
cuh00290  Valine, leucine and isoleucine biosynthesis
cuh00290

Module
cuh_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cuh00290]
cuh_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:cuh00290]
cuh_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:cuh00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Cupriavidus necator NH9 [GN:cuh]
Gene
BJN34_02650  threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BJN34_14045  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BJN34_23355  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BJN34_26705  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BJN34_30375  isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BJN34_20325  3-isopropylmalate dehydratase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BJN34_33795  3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BJN34_14035  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BJN34_23350  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BJN34_26710  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BJN34_30380  isopropylmalate isomerase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BJN34_20320  3-isopropylmalate dehydratase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BJN34_33800  3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BJN34_14030  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
BJN34_24875  hypothetical protein [KO:K01652] [EC:2.2.1.6]
BJN34_24565  acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
BJN34_30525  acetolactate synthase, large subunit, biosynthetic type [KO:K01652] [EC:2.2.1.6]
BJN34_05500  acetolactate synthase, large subunit, biosynthetic type [KO:K01652] [EC:2.2.1.6]
BJN34_11340  thiamine pyrophosphate-binding protein [KO:K01652] [EC:2.2.1.6]
BJN34_05505  acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
BJN34_05510  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
BJN34_22515  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
BJN34_15970  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BJN34_23035  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
BJN34_25380  branched-chain amino acid--2-keto-4-methylthiobutyrate aminotransferase [KO:K00826] [EC:2.6.1.42]
BJN34_03390  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
BJN34_24955  Glu/Leu/Phe/Val dehydrogenase [KO:K00263] [EC:1.4.1.9]
BJN34_11565  aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
BJN34_20420  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
BJN34_05530  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
cuh00260  Glycine, serine and threonine metabolism
cuh00280  Valine, leucine and isoleucine degradation
cuh00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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