KEGG   PATHWAY: cuh00260
Entry
cuh00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cupriavidus necator NH9
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cuh00260  Glycine, serine and threonine metabolism
cuh00260

Module
cuh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cuh00260]
cuh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cuh00260]
cuh_M00555  Betaine biosynthesis, choline => betaine [PATH:cuh00260]
cuh_M00621  Glycine cleavage system [PATH:cuh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cupriavidus necator NH9 [GN:cuh]
Gene
BJN34_06425  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BJN34_14025  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BJN34_11560  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BJN34_14780  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BJN34_11555  threonine synthase [KO:K01733] [EC:4.2.3.1]
BJN34_14870  threonine aldolase [KO:K01620] [EC:4.1.2.48]
BJN34_15255  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BJN34_27510  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BJN34_26850  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BJN34_00845  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BJN34_25370  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BJN34_28595  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BJN34_13855  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BJN34_26855  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BJN34_37180  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BJN34_30745  glycerate kinase [KO:K11529] [EC:2.7.1.165]
BJN34_19240  glycerate kinase [KO:K11529] [EC:2.7.1.165]
BJN34_10915  glycerate kinase [KO:K11529] [EC:2.7.1.165]
BJN34_02125  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BJN34_03045  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
BJN34_19800  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJN34_25220  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BJN34_04460  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BJN34_07355  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BJN34_25195  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BJN34_13275  amine oxidase [KO:K00274] [EC:1.4.3.4]
BJN34_13320  amine oxidase [KO:K00274] [EC:1.4.3.4]
BJN34_19330  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BJN34_19320  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BJN34_27160  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJN34_07020  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJN34_11840  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BJN34_19325  glycine cleavage system protein H [KO:K02437]
BJN34_27280  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BJN34_05520  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BJN34_33210  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BJN34_33205  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BJN34_34525  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BJN34_35765  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BJN34_36325  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BJN34_19335  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BJN34_02650  threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BJN34_27700  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
BJN34_08390  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BJN34_25560  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BJN34_13995  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BJN34_14005  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cuh00010  Glycolysis / Gluconeogenesis
cuh00020  Citrate cycle (TCA cycle)
cuh00230  Purine metabolism
cuh00250  Alanine, aspartate and glutamate metabolism
cuh00270  Cysteine and methionine metabolism
cuh00290  Valine, leucine and isoleucine biosynthesis
cuh00300  Lysine biosynthesis
cuh00330  Arginine and proline metabolism
cuh00460  Cyanoamino acid metabolism
cuh00470  D-Amino acid metabolism
cuh00564  Glycerophospholipid metabolism
cuh00600  Sphingolipid metabolism
cuh00620  Pyruvate metabolism
cuh00630  Glyoxylate and dicarboxylate metabolism
cuh00640  Propanoate metabolism
cuh00680  Methane metabolism
cuh00860  Porphyrin metabolism
cuh00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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