KEGG   PATHWAY: dsi03420
Entry
dsi03420                    Pathway                                
Name
Nucleotide excision repair - Drosophila simulans
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
dsi03420  Nucleotide excision repair
dsi03420

Other DBs
GO: 0006289
Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD11014  Dsim_GD11014; uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dsimw501_GD11042  Dsim_GD11042; uncharacterized protein, isoform A [KO:K03141]
Dsimw501_GD11080  Dsim_GD11080; uncharacterized protein [KO:K10849]
Dsimw501_GD11107  Dsim_GD11107; uncharacterized protein, isoform B [KO:K10838]
Dsimw501_GD11571  Dsim_GD11571; uncharacterized protein [KO:K10844] [EC:5.6.2.3]
Dsimw501_GD11667  Dsim_GD11667; uncharacterized protein [KO:K03506] [EC:2.7.7.7]
Dsimw501_GD11985  Dsim_GD11985; uncharacterized protein [KO:K10845]
Dsimw501_GD12524  Dsim_GD12524; uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dsimw501_GD12553  Dsim_GD12553; uncharacterized protein [KO:K03144]
Dsimw501_GD13171  Dsim_GD13171; uncharacterized protein, isoform A [KO:K02325] [EC:2.7.7.7]
Dsimw501_GD13291  Dsim_GD13291; uncharacterized protein [KO:K10755]
Dsimw501_GD13645  Dsim_GD13645; uncharacterized protein [KO:K02328]
Dsimw501_GD14248  Dsim_GD14248; uncharacterized protein [KO:K10843] [EC:5.6.2.4]
Dsimw501_GD14989  Dsim_GD14989; uncharacterized protein [KO:K03016]
Dsimw501_GD15002  Dsim_GD15002; uncharacterized protein [KO:K06634]
Dsimw501_GD15058  Dsim_GD15058; uncharacterized protein [KO:K03142]
Dsimw501_GD15257  Dsim_GD15257; uncharacterized protein [KO:K03013]
Dsimw501_GD15662  Dsim_GD15662; uncharacterized protein [KO:K10755]
Dsimw501_GD15982  Dsim_GD15982; uncharacterized protein [KO:K10740]
Dsimw501_GD15986  Dsim_GD15986; uncharacterized protein [KO:K03006] [EC:2.7.7.6]
Dsimw501_GD16302  Dsim_mei-9; mei-9 [KO:K10848] [EC:3.1.-.-]
Dsimw501_GD16520  Dsim_GD16520; uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dsimw501_GD18880  Dsim_GD18880; uncharacterized protein [KO:K10610]
Dsimw501_GD18948  Dsim_GD18948; uncharacterized protein [KO:K03010] [EC:2.7.7.6]
Dsimw501_GD18953  Dsim_GD18953; uncharacterized protein [KO:K03017]
Dsimw501_GD19279  Dsim_GD19279; uncharacterized protein [KO:K21987]
Dsimw501_GD19753  Dsim_GD19753; uncharacterized protein [KO:K10754]
Dsimw501_GD19782  Dsim_GD19782; uncharacterized protein [KO:K03014]
Dsimw501_GD20190  Dsim_GD20190; uncharacterized protein, isoform D [KO:K03012]
Dsimw501_GD20374  Dsim_GD20374; uncharacterized protein [KO:K03015]
Dsimw501_GD20882  Dsim_GD20882; uncharacterized protein [KO:K07466]
Dsimw501_GD21012  Dsim_GD21012; uncharacterized protein [KO:K02324] [EC:2.7.7.7]
Dsimw501_GD21063  Dsim_GD21063; uncharacterized protein [KO:K10839]
Dsimw501_GD21123  Dsim_GD21123; uncharacterized protein [KO:K03007]
Dsimw501_GD21666  Dsim_GD21666; uncharacterized protein [KO:K10739]
Dsimw501_GD21742  Dsim_GD21742; uncharacterized protein, isoform A [KO:K04802]
Dsimw501_GD21874  Dsim_GD21874; uncharacterized protein [KO:K03008]
Dsimw501_GD21967  Dsim_GD21967; uncharacterized protein [KO:K03504]
Dsimw501_GD22189  Dsim_GD22189; uncharacterized protein [KO:K10756]
Dsimw501_GD22925  Dsim_GD22925; uncharacterized protein [KO:K03143]
Dsimw501_GD23542  Dsim_GD23542; uncharacterized protein [KO:K02326] [EC:2.7.7.7]
Dsimw501_GD23543  Dsim_GD23543; uncharacterized protein [KO:K10846]
Dsimw501_GD23698  Dsim_GD23698; uncharacterized protein [KO:K10756]
Dsimw501_GD23930  Dsim_GD23930; uncharacterized protein [KO:K03011]
Dsimw501_GD24402  Dsim_Rad23; Rad23 [KO:K10839]
Dsimw501_GD24595  Dsim_GD24595; uncharacterized protein [KO:K02202] [EC:2.7.11.22 2.7.11.23]
Dsimw501_GD25292  Dsim_mus209; mus209 [KO:K04802]
Dsimw501_GD25636  Dsim_GD25636; uncharacterized protein [KO:K03009]
Dsimw501_GD25961  Dsim_GD25961; uncharacterized protein [KO:K10842]
Dsimw501_GD27026  Dsim_GD27026; uncharacterized protein [KO:K10609]
Dsimw501_GD27274  Dsim_GD27274; uncharacterized protein [KO:K10847]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
dsi03020  RNA polymerase
dsi04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

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