KEGG   PATHWAY: ko03420
ko03420                     Pathway                                
Nucleotide excision repair
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
Pathway map
ko03420  Nucleotide excision repair

Other DBs
GO: 0006289
K03723  transcription-repair coupling factor (superfamily II helicase) [EC:]
K03701  excinuclease ABC subunit A
K03702  excinuclease ABC subunit B
K03703  excinuclease ABC subunit C
K03657  ATP-dependent DNA helicase UvrD/PcrA [EC:]
K02335  DNA polymerase I [EC:]
K01972  DNA ligase (NAD+) [EC:]
K03868  E3 ubiquitin-protein ligase RBX1 [EC:]
K10609  cullin 4
K10610  DNA damage-binding protein 1
K10140  DNA damage-binding protein 2
K10838  xeroderma pigmentosum group C-complementing protein
K10839  UV excision repair protein RAD23
K10840  centrin-2
K10570  DNA excision repair protein ERCC-8
K10841  DNA excision repair protein ERCC-6
K02202  cyclin-dependent kinase 7 [EC:]
K10842  CDK-activating kinase assembly factor MAT1
K06634  cyclin H
K10843  DNA excision repair protein ERCC-3 [EC:]
K10844  DNA excision repair protein ERCC-2 [EC:]
K10845  TFIIH basal transcription factor complex TTD-A subunit
K03141  transcription initiation factor TFIIH subunit 1
K03142  transcription initiation factor TFIIH subunit 2
K03143  transcription initiation factor TFIIH subunit 3
K03144  transcription initiation factor TFIIH subunit 4
K10846  DNA excision repair protein ERCC-5
K10847  DNA-repair protein complementing XP-A cells
K07466  replication factor A1
K10739  replication factor A2
K10740  replication factor A3
K10741  replication factor A4
K10848  DNA excision repair protein ERCC-4 [EC:3.1.-.-]
K10849  DNA excision repair protein ERCC-1
K02327  DNA polymerase delta subunit 1 [EC:]
K02328  DNA polymerase delta subunit 2
K03504  DNA polymerase delta subunit 3
K03505  DNA polymerase delta subunit 4
K02324  DNA polymerase epsilon subunit 1 [EC:]
K02325  DNA polymerase epsilon subunit 2 [EC:]
K02326  DNA polymerase epsilon subunit 3 [EC:]
K03506  DNA polymerase epsilon subunit 4 [EC:]
K04802  proliferating cell nuclear antigen
K10754  replication factor C subunit 1
K10755  replication factor C subunit 2/4
K10756  replication factor C subunit 3/5
K10747  DNA ligase 1 [EC:]
Sugasawa K.
[Molecular mechanism of mammalian nucleotide excision repair]
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Nakatsu Y.
[Transcription-coupled repair and Cockayne syndrome]
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
Sugasawa K.
[DNA repair pathways involving Cul4A ubiquitin ligases]
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
ko03020  RNA polymerase
ko04120  Ubiquitin mediated proteolysis

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