KEGG   PATHWAY: ebe00290
Entry
ebe00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Escherichia coli BL21(DE3)
Class
Metabolism; Amino acid metabolism
Pathway map
ebe00290  Valine, leucine and isoleucine biosynthesis
ebe00290

Module
ebe_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ebe00290]
ebe_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ebe00290]
ebe_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ebe00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Escherichia coli BL21(DE3) [GN:ebe]
Gene
B21_02935  tdcB; catabolic threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B21_03599  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
B21_00073  leuC; leuC, subunit of isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
B21_00072  leuD; leuD, subunit of isopropylmalate isomerase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
B21_00074  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
B21_00078  ilvI; ilvI, subunit of acetohydroxybutanoate synthase / acetolactate synthase [KO:K01652] [EC:2.2.1.6]
B21_03595  ilvG; acetolactate synthase II, large subunit [KO:K01652] [EC:2.2.1.6]
B21_03497  ilvB; ilvB, subunit of acetolactate synthase / acetohydroxybutanoate synthase [KO:K01652] [EC:2.2.1.6]
B21_00079  ilvH; ilvH, subunit of acetohydroxybutanoate synthase / acetolactate synthase [KO:K01653] [EC:2.2.1.6]
B21_03496  ilvN; ilvN, subunit of acetolactate synthase / acetohydroxybutanoate synthase [KO:K01653] [EC:2.2.1.6]
B21_03596  ilvM; acetolactate synthase / acetohydroxybutanoate synthase [KO:K11258] [EC:2.2.1.6]
B21_03601  ilvC; acetohydroxy acid isomeroreductase [KO:K00053] [EC:1.1.1.86]
B21_03598  ilvD; dihydroxy acid dehydratase [KO:K01687] [EC:4.2.1.9]
B21_03597  ilvE; branched-chain amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
B21_03375  avtA; valine-pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
B21_02175  yfbQ; predicted aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
B21_00075  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ebe00260  Glycine, serine and threonine metabolism
ebe00280  Valine, leucine and isoleucine degradation
ebe00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

DBGET integrated database retrieval system