KEGG PATHWAY: ebe00260

PATHWAY: ebe00260

Entry

ebe00260                    Pathway

Name

Glycine, serine and threonine metabolism - Escherichia coli BL21(DE3)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ebe00260

Glycine, serine and threonine metabolism

Module

ebe_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ebe00260]

ebe_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ebe00260]

ebe_M00555

Betaine biosynthesis, choline => betaine [PATH:ebe00260]

ebe_M00621

Glycine cleavage system [PATH:ebe00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Escherichia coli BL21(DE3) [GN:ebe]

Gene

B21_03856

lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]

B21_00002

thrA; homoserine dehydrogenase / aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]

B21_03775

metL; homoserine dehydrogenase / aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]

B21_03238

asd; aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

B21_00003

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

B21_00004

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

B21_00881

ltaE; LtaA, subunit of low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]

B21_02407

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

B21_01037

ghrA; glyoxylate reductase / hydroxypyruvate reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]

B21_03354

ghrB; 2-ketoaldonate reductase / glyoxylate reductase B / glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

B21_00469

glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]

B21_02940

garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]

B21_00697

gpmA; phosphoglyceromutase 1 monomer, subunit of phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]

B21_04236

ytjC; phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]

B21_03421

gpmM; phosphoglycerate mutase, cofactor independent [KO:K15633] [EC:5.4.2.12]

B21_02707

serA; D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

B21_00918

serC; 3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]

B21_04229

serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

B21_01509

ydfG; 3-hydroxy acid dehydrogenase monomer, subunit of 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]

B21_03426

kbl; 2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]

B21_03425

tdh; threonine dehydrogenase [KO:K00060] [EC:1.1.1.103]

B21_02698

gcvP; glycine decarboxylase, subunit of glycine cleavage system [KO:K00281] [EC:1.4.4.2]

B21_02700

gcvT; aminomethyltransferase, subunit of glycine cleavage system [KO:K00605] [EC:2.1.2.10]

B21_00114

lpd; E3 monomer, subunit of lipoamide dehydrogenase, pyruvate dehydrogenase multienzyme complex, glycine cleavage system and 2-oxoglutarate dehydrogenase complex [KO:K00382] [EC:1.8.1.4]

B21_02699

gcvH; glycine cleavage system H protein [KO:K02437]

B21_02443

pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]

B21_00270

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

B21_00271

betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

B21_01772

sdaA; L-serine deaminase I [KO:K01752] [EC:4.3.1.17]

B21_02604

sdaB; L-serine deaminase II [KO:K01752] [EC:4.3.1.17]

B21_02930

tdcG; L-serine deaminase III [KO:K01752] [EC:4.3.1.17]

B21_02935

tdcB; catabolic threonine dehydratase [KO:K01754] [EC:4.3.1.19]

B21_03599

ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]

B21_02237

dsdA; D-serine deaminase [KO:K01753] [EC:4.3.1.18]

B21_02649

ygeA; predicted racemase [KO:K25316] [EC:5.1.1.10]

B21_01244

trpA; tryptophan synthase, alpha subunit, subunit of tryptophan synthase [KO:K01695] [EC:4.2.1.20]

B21_01245

trpB; tryptophan synthase, beta subunit, subunit of tryptophan synthase, beta subunit dimer and tryptophan synthase [KO:K01696] [EC:4.2.1.20]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721