Entry Name ABC transporters - Escherichia coli K-12 W3110
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Escherichia coli K-12 W3110 [GN:
ecj ]
Gene JW0066 thiP; fused subunits of thiamin transporter and membrane components of ABC superfamily [KO:K02063 ]
JW0148 fhuD; iron-hydroxamate transporter subunit [KO:K23227 ]
JW0149 fhuB; fused subunits of iron-hydroxamate transporter and membrane components of ABC superfamily transporter [KO:K23228 ]
JW0255 afuB; predicted ferric trasnporter subunit [KO:K02011 ]
JW0438 mdlA; fused predicted multidrug transporter subunits and ATP-binding components of ABC superfamily [KO:K18889 ]
JW0580 fepC; iron-enterobactin transporter subunit [KO:K23188 ]
JW0581 fepG; iron-enterobactin transporter subunit [KO:K23187 ]
JW0582 fepD; iron-enterobactin transporter subunit [KO:K23186 ]
JW0584 fepB; iron-enterobactin transporter subunit [KO:K23185 ]
JW0648 gltK; glutamate and aspartate transporter subunit [KO:K10002 ]
JW0649 gltJ; glutamate and aspartate transporter subunit [KO:K10003 ]
JW0743 modF; fused subunits of molybdate transporter and ATP-binding components of ABC superfamily [KO:K05776 ]
JW0815 yliC; predicted peptide transporter subunit [KO:K13890 ]
JW0816 yliD; predicted peptide transporter subunit [KO:K13891 ]
JW0863 macB; fused macrolide transporter subunits and ATP-binding component and membrane component of ABC superfamily [KO:K05685 ] [EC:7.6.2.-]
JW0869 cydC; fused cysteine transporter subunits and membrane component and ATP-binding component of ABC superfamily [KO:K16012 ]
JW0870 cydD; fused cysteine transporter subunits and membrane component and ATP-binding component of ABC superfamily [KO:K16013 ]
JW0897 msbA; fused lipid transporter subunits and membrane component and ATP-binding component of ABC superfamily [KO:K11085 ] [EC:7.5.2.6 ]
JW0919 ssuA; alkanesulfonate transporter subunit [KO:K15553 ]
JW1104 lolE; outer membrane-specific lipoprotein transporter subunit [KO:K09808 ]
JW1283 sapF; predicted antimicrobial peptide transporter subunit [KO:K19230 ]
JW1284 sapD; predicted antimicrobial peptide transporter subunit [KO:K19229 ]
JW1285 sapC; predicted antimicrobial peptide transporter subunit [KO:K19228 ]
JW1286 sapB; predicted antimicrobial peptide transporter subunit [KO:K19227 ]
JW1287 sapA; predicted antimicrobial peptide transporter subunit [KO:K19226 ]
JW1311 ycjV; predicted sugar transporter subunit [KO:K10112 ] [EC:7.5.2.-]
JW1322 mppA; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit [KO:K15580 ]
JW1506 ego; fused AI2 transporter subunits and ATP-binding components of ABC superfamily [KO:K10558 ]
JW1887 araH; fused L-arabinose transporter subunits and membrane components of ABC superfamily [KO:K10538 ]
JW1888 araG; fused L-arabinose transporter subunits and ATP-binding components of ABC superfamily [KO:K10539 ] [EC:7.5.2.12 ]
JW2135 mglC; methyl-galactoside transporter subunit [KO:K10541 ]
JW2136 mglA; fused methyl-galactoside transporter subunitsl and ATP-binding components of ABC superfamily [KO:K10542 ] [EC:7.5.2.11 ]
JW2137 mglB; methyl-galactoside transporter subunit [KO:K10540 ]
JW2165 yejA; predicted oligopeptide transporter subunit [KO:K13893 ]
JW2166 yejB; predicted oligopeptide transporter subunit [KO:K13894 ]
JW2167 yejE; predicted oligopeptide transporter subunit [KO:K13895 ]
JW2168 yejF; fused predicted oligopeptide transporter subunits and ATP-binding components of ABC superfamily [KO:K13896 ]
JW2199 yojI; fused predicted multidrug transport subunits and membrane component and ATP-binding component of ABC superfamily [KO:K06159 ]
JW2304 hisM; histidine/lysine/arginine/ornithine transporter subunit [KO:K10015 ]
JW2305 hisQ; histidine/lysine/arginine/ornithine transporter subunit [KO:K10016 ]
JW2306 hisJ; histidine/lysine/arginine/ornithine transporter subunit [KO:K10014 ]
JW2307 argT; lysine/arginine/ornithine transporter subunit [KO:K10013 ]
JW2416 cysW; sulfate/thiosulfate transporter subunit [KO:K02047 ]
JW2417 cysU; sulfate/thiosulfate transporter subunit [KO:K02046 ]
JW2530 yphD; predicted sugar transporter subunit [KO:K23546 ]
JW2531 yphE; fused predicted sugar transporter subunits and ATP-binding components of ABC superfamily [KO:K23547 ]
JW2532 yphF; predicted sugar transporter subunit [KO:K23545 ]
JW2653 proW; glycine betaine transporter subunit [KO:K02001 ]
JW2654 proX; glycine betaine transporter subunit [KO:K02002 ]
JW3159 yrbC; predicted ABC-type organic solvent transporter [KO:K07323 ]
JW3160 yrbD; predicted ABC-type organic solvent transporter [KO:K02067 ]
JW3161 yrbE; predicted toluene transporter subunit [KO:K02066 ]
JW3162 yrbF; predicted toluene transporter subunit [KO:K02065 ]
JW3236 yhdW; predicted amino-acid transporter subunit [KO:K09969 ]
JW3416 ugpE; glycerol-3-phosphate transporter subunit [KO:K05815 ]
JW3417 ugpA; glycerol-3-phosphate transporter subunit [KO:K05814 ]
JW3418 ugpB; glycerol-3-phosphate transporter subunit [KO:K05813 ]
JW3419 livF; leucine/isoleucine/valine transporter subunit [KO:K01996 ]
JW3420 livG; leucine/isoleucine/valine transporter subunit [KO:K01995 ]
JW3421 livM; leucine/isoleucine/valine transporter subunit [KO:K01998 ]
JW3422 livH; leucine/isoleucine/valine transporter subunit [KO:K01997 ]
JW3425 livJ; leucine/isoleucine/valine transporter subunit [KO:K01999 ]
JW3539 xylG; fused subunits of D-xylose transporter and ATP-binding components of ABC superfamily [KO:K10545 ] [EC:7.5.2.10 ]
JW3635 nlpA; cytoplasmic membrane lipoprotein-28 [KO:K02073 ]
JW3728 rbsA; fused D-ribose transporter subunits and ATP-binding components ABC superfamily [KO:K10441 ] [EC:7.5.2.7 ]
JW3995 malK; fused maltose transport subunit, ATP-binding component of ABC superfamily and regulatory protein [KO:K10111 ] [EC:7.5.2.-]
JW4048 alsA; fused D-allose transporter subunits and ATP-binding components of ABC superfamily [KO:K10551 ] [EC:7.5.2.8 ]
JW4066 phnD; phosphonate/organophosphate ester transporter subunit [KO:K02044 ]
JW4186 ytfQ; predicted sugar transporter subunit [KO:K23508 ]
JW5061 mdlB; fused predicted multidrug transporter subunits and ATP binding components of ABC superfamily [KO:K18890 ]
JW5092 gltI; glutamate and aspartate transporter subunit [KO:K10001 ]
JW5111 yliB; predicted peptide transporter subunit [KO:K13889 ]
JW5121 ssuC; alkanesulfonate transporter subunit [KO:K15554 ]
JW5161 lolC; outer membrane-specific lipoprotein transporter subunit [KO:K09808 ]
JW5162 lolD; outer membrane-specific lipoprotein transporter subunit [KO:K09810 ] [EC:7.6.2.-]
JW5242 yddA; fused predicted multidrug transporter subunits and membrane component and ATP-binding component of ABC superfamily [KO:K02471 ]
JW5544 yhdX; predicted amino-acid transporter subunit [KO:K09970 ]
JW5545 yhdY; predicted amino-acid transporter subunit [KO:K09971 ]
JW5753 ytfT; predicted sugar transporter subunit [KO:K23509 ]
JW5754 yjfF; predicted sugar transporter subunit [KO:K23509 ]
JW5897 yliA; fused predicted peptide transport subunits and ATP-binding components of ABC superfamily [KO:K13892 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
